Today is

Elizabeth Stephens, Ph.D.

Medical School

Undergraduate Institution: University of California - San Diego

Year: Fourth-Year Medical Student

Graduate Program: Bioengineering (Rice University)

Mentor: K. Jane Grande-Allen, Ph.D.

Thesis Title: Composition, Turnover, and Mechanics of Extracellular Matrix in Developing, Aging, and Pathological Valves

Publications:

Stephens EH, Kearney DL, Grande-Allen KJ. Insight into pathologic abnormalities in congenital semilunar valve disease based on advances in understanding normal valve microstructure and extracellular matrix. Cardiovascular pathology: the official journal of the Society for Cardiovascular Pathology. 2012;21(1):46-58.
Stephens EH, Shangkuan J, Kuo JJ, Carroll JL, Kearney DL, Carberry KE, Fraser CD, Jr., Grande-Allen KJ. Extracellular matrix remodeling and cell phenotypic changes in dysplastic and hemodynamically altered semilunar human cardiac valves. Cardiovascular pathology: the official journal of the Society for Cardiovascular Pathology. 2011;20(5):e157-67.
Stephens EH, Saltarrelli JG, Baggett LS, Nandi I, Kuo JJ, Davis AR, Olmsted-Davis EA, Reardon MJ, Morrisett JD, Grande-Allen KJ. Differential proteoglycan and hyaluronan distribution in calcified aortic valves. Cardiovascular pathology: the official journal of the Society for Cardiovascular Pathology. 2011;20(6):334-42.
Stephens EH, Durst CA, West JL, Grande-Allen KJ. Mitral valvular interstitial cell responses to substrate stiffness depend on age and anatomic region. Acta biomaterialia. 2011;7(1):75-82.
Stephens EH, Post AD, Laucirica DR, Grande-Allen KJ. Perinatal changes in mitral and aortic valve structure and composition. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. 2010;13(6):447-58.
Stephens EH, Carroll JL, Post AD, Kuo JJ, Grande-Allen KJ. Functional characterization of fibronectin-separated valve interstitial cell subpopulations in three-dimensional culture. The Journal of heart valve disease. 2010;19(6):759-65.
Stephens EH, de Jonge N, McNeill MP, Durst CA, Grande-Allen KJ. Age-related changes in material behavior of porcine mitral and aortic valves and correlation to matrix composition. Tissue Eng Part A. 2010. 16(3):867-78.
Stephens EH, Huynh TN, Cieluch JD, Grande-Allen KJ. Fibronectin-based isolation of valve interstitial cell subpopulations: Relevance to valve disease. J Biomed Mater Res A. 2010. 92(1):340-9.
Gupta V, Barzilla JE, Mendez JS, Stephens EH, Lee EL, Collard CD, Laucirica R, Weigel PH, Grande-Allen KJ. Abundance and location of proteoglycans and hyaluronan within normal and myxomatous mitral valves. Cardiovasc Pathol. 2009. 18(4):191-7.
Stephens EH, Timek TA, Daughters GT, Kuo JJ, Patton AM, Baggett LS, Ingels NB, Jr., Miller DC, Grande-Allen KJ. Significant changes in mitral valve leaflet matrix composition and turnover with tachycardia-induced cardiomyopathy. Circulation. 2009. 120(11 Suppl):S112-9.
Gupta V, Werdenberg JA, Lawrence BD, Mendez JS, Stephens EH, Grande-Allen KJ. Reversible secretion of glycosaminoglycans and proteoglycans by cyclically stretched valvular cells in 3D culture. Ann Biomed Eng. 2008. 36(7):1092-103.
Stephens EH, Chu CK, Grande-Allen KJ. Valve proteoglycan content and glycosaminoglycan fine structure are unique to microstructure, mechanical load and age: Relevance to an age-specific tissue-engineered heart valve. Acta Biomater. 2008. 4(5):1148-60.
Stephens EH, Nguyen TC, Itoh A, Ingels NB, Miller CD, Grande-Allen KJ. The effects of hemodynamics of regurgitation alone are sufficient for mitral valve leaflet remodeling. Circulation. 2008. 118(11):S243-9.
Stephens EH, Carroll JL, Grande-Allen KJ. The use of collagenase III for the isolation of porcine aortic valvular interstitial cells: rationale and optimization. J Heart Valve Dis. 2007. 16(2):175-83.
Stephens EH, Grande-Allen KJ. Age-related changes in collagen synthesis and turnover in porcine heart valves. J Heart Valve Dis. 2007. 16(6):672-82.