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Jennifer Gatchel, Ph.D.

Neuroscience

Undergraduate Institution: University of Texas - Austin

Year: Advanced Medical Student

Mentor: Huda Zoghbi, M.D.

Thesis Title: Transcriptional Dysregulation in the Pathogenesis of Spinocerebellar Ataxia Type 1 (SCA1) and Spinocerebellar Ataxia Type 7 (SCA7)

Publications:

Lee Y, Samaco RC, Gatchel JR, Thaller C, Orr HT, Zoghbi HY. miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis. Nat Neurosci. 2008; (11)10:1137-9.

Gatchel JR, Watase K, Thaller C, Carson JP, Jafar-Nejad P, Shaw C, Zu T, Orr HT, Zoghbi HY. The insulin-like growth factor pathway is altered in spinocerebellar ataxia type 1 and type 7. Proc Natl Acad Sci USA. 2008; (105)4:1291-6.

Watase K, Gatchel JR, Sun Y, Emamian E, Atkinson R, Richman R, Mizusawa H, Orr HT, Shaw C, Zoghbi HY. Lithium therapy improves neurological function and hippocampal dendritic arborization in a spinocerebellar ataxia type 1 mouse model. PLoS Med. 2007; (4)5:e182.

Gatchel JR, Zoghbi HY. Diseases of unstable repeat expansion: mechanisms and common principles. Nat Rev Genet. 2005; (6)10:743-55.

Varga AW, Yuan LL, Anderson AE, Schrader LA, Wu GY, Gatchel JR, Johnston D, Sweatt JD. Calcium-calmodulin-dependent kinase II modulates Kv4.2 channel expression and upregulates neuronal A-type potassium currents. J Neurosci. 2004; (24)14:3643-54.