Replication and Gene Expression in Viral Systems
Course covers advanced principles of viral genome replication and gene expression, as observed in infected cells and through expression of isolated viral genes. Genome replication of both RNA and DNA viruses is covered, with emphasis on the newly emerging information on RNA replication. The specific effects of viral proteins on initiation of transcription, transcriptional elongation, mRNA processing, and translation of viral and cellular genes are discussed. The use of viruses as probes to investigate cellular gene regulation is discussed. Critical evaluation of the current literature is emphasized. (Even years, Term 4)
Meeting |
Topic |
Faculty |
1 |
Introduction | Marriott |
2 |
Retrovirus Replication – PIC import | Marriott |
3 |
RNA Virus Replication | Lloyd |
4 |
DNA Virus Replication - Role of PML Bodies PROPOSAL TOPIC DUE |
Marriott |
5 |
Herpesvirus LMP function | Ken Izumi |
6 |
Effect of Chromatin on Viral Transactivators | Marriott |
7 |
Genetic Approaches to Viral Transcription Factor Function | Ling |
8 |
Viral Mimicry of Cellular Signaling | Ling |
9 |
Mechanisms for Specificity of Viral Transactivators | Ling |
10 |
The HIV-1 Nef protein PROPOSALS DUE |
Rice |
11 |
Hepatitis C Virus Replication | Robert Lanford |
12 |
Transcriptional elongation, HIV-1 Tat protein | Rice |
13 |
Post transcriptional regulation by retroviral CTE | Rice |
14 |
Translational Control | Lloyd |
15 |
Translational Control | Lloyd |
16 |
Engineering Viruses for Oncolytic Purposes - from Imagination
to Reality REVISED PROPOSALS DUE |
Shaun X-L Zhang |
17 |
Final Exam |