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Our research is focused on the development of the high throughput methodology for electron cryomicroscopy and computational methods to solve 3-dimensional structures of macromolecular machines towards atomic resolution. The biological applications of our methodology include viruses, ion channels, membranes, oligomeric proteins and cyotskeletal protein complexes. Research effort is made to derive functions of the machine components via computational approaches.

Recent Publications (PubMed)

Baker, M. L., Jiang, W., Wedemeyer, W. J., Rixon, F. J., Baker, D. and Chiu, W. (2006). Ab initio modeling of the Herpesvirus VP26 core domain assessed by cryoEM density. PLoS Comput Biol 2(11): e146.

Jiang, W., Chang, J., Jakana, J. Weigele, P., King, J. and Chiu, W. (2006). Structure of epsilon15 bacteriophage reveals genome organization and DNA packaging/injection apparatus. Nature, 439: 612-6.

Chang, J., Weigele, P., King, J., Chiu, W., and Jiang, W. (2006). Cryo-EM asymmetric reconstruction of bacteriophage P22 reveals organization of its DNA packaging and infecting machinery. Structure 14: 1073-1082.

Johnson, J.E. and Chiu, W. (2007). DNA packaging and delivery machines in tailed bacteriophages. Curr Opin Struct Biol, 17: 237-43.

Chang, J., M. F. Schmid, F. Rixon, and Chiu, W. (2007). Electron cryo-tomography reveals the portal in the herpesvirus capsid. J Virol, 81: 2065-2068.

Jiang, W., M.L. Baker, J. Jakana, P.R. Weigele, J. King, and W. Chiu (2008). Backbone structure of the infectious epsilon15 virus capsid revealed by electron cryomicroscopy. Nature 451: 1130-4.

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