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Thrombosis Research Section Faculty
Full-Time Faculty (Primary Appointment)
Research Interests:
Several clinical studies including ours have identified PlA2 allele
as a risk factor for coronary heart disease (CAD). Dr Vijayan's research
interest is focused on identifying the molecular mechanisms underlying
the involvement of PlA2 allele with CAD. His studies include 1) Characterizing
differential adhesive functions between the PlA1 and PlA2 allele to
the extracellular matrix proteins under shear and static conditions.
2) Identifying signaling differences between the two alleles in response
to fibrinogen binding. 3) Understanding the role of PlA2 allele in
modifying the effects of estrogen. These studies will shed light on
the thrombotic risk associated with PlA2 polymorphism.
Recent Publications:
1. Vijayan, K.V., Huang, T.C., Liu, Y., Bernardo A., Dong, J.F.,
Alevriadou R.B., and Bray P.F. Shear stress augments the enhanced
adhesive phenotype of cells expressing the Pro33 isoform of integrin
b3. FEBS Lett.
2003;540:41-46.
2. Vijayan, K.V., Liu, Y., Dong, J.F., and Bray P.F. Enhanced activation
of mitogen-activated protein kinase and myosin light chain kinase
by the Pro33 polymorphism of integrin b3.
J Biol Chem. 2003;278(6):3860-3867.
3. Sajid M., Vijayan, K.V, Souza S.N., and Bray P.F. PlA polymorphism
of integrin b3
differentially modulates cellular migration on extracellular matrix
proteins. Arterioscler Throm Vasc Biol 2002;22(12):1984-1989.
4. Nealen, M.L., Vijayan, K.V., Bolton, E.D., Bray P.F. Human Platelets
contain a glycosylated estrogen receptor b
(ER b). Circ Res 2001;88(4):438-42.
5. Khetawat, G., Faraday, N., Nealen, M., Vijayan, K.V., Bolton,
E., Noga, S. J., Bray, P.F. Human megakaryocytes and platelets contain
the estrogen receptor b and androgen receptor
(AR): Testosterone regulates AR expression. Blood 2000;95(7):2289-96.
6. Vijayan, K.V., Goldschmidt-Clermont, P. J., Roos, C. M., Bray,
P. F. The PlA2 polymorphism of integrin b3 enhances outside-in signaling
and adhesive functions. J Clin Invest 2000;105(6):793-802.
7. Vijayan, K.V., Advani, S.H. Zingde, S. M. Chronic Myeloid leukemic
granulocytes exhibit reduced and altered binding to P-selectin. Modification
in the CD15 antigens and sialylation. Leuk Res 1997;21(1):59-65.
8. Vijayan, V.K. and Zingde S. M. Heat treated Bovine Albumin is
a better blocking reagent for adhesion studies. BioTechniques
1995;18(3):430-432.
9. Vijayan, K.V., Advani, S. H. and Zingde, S. M. Chronic Myeloid
Leukemic granulocytes exhibit decreased adhesion to fibronectin. Leuk
Res 1994;18(12):877-879.
 ©1995-2003
Baylor College of Medicine
Email: medicine@bcm.tmc.edu
URL: http://public.bcm.tmc.edu/medicine/vijayan.htm (Modified:June 6, 2003)
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