Thrombosis Leadership
Jing-Fei Dong, M.D., PH.D.
Acting Chief and Associate Professor of Thrombosis Research
Director, Thrombosis Core Laboratory
Co-Director, Shear and Flow Cytometry Laboratory
Research Interests:
Research in our group has been concentrated on platelet functions under high fluid shear stress. Our aim is to understand how platelets interact with subendothelium, with each other, and with other blood cells under flow condition. We are particularly interested in dissecting signal pathways that are initiated by the interaction of platelet glycoprotein Ib-IX-V complex and von Willebrand factor. Our research also focuses on defining mechanisms through which the endothelium-derived ultra-large von Willebrand factor multimers are cleaved by the ADAMTS-13 metalloprotease in vivo and what roles of this proteolysis process may play in the development of thrombosis. Such efforts will allow us to identify agents that selectively block pathophysiological thrombosis without affecting physioligcal hemostatic function of platelets.