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Thrombosis Research Section Faculty
Full-Time Faculty (Primary Appointment)
Research Interests:
My main area of research is the integrin monomer b3.
b3 integrin complexes exclusively with
the aIIb integrin in cells of megakaryocytic
lineage and with the av integrin in other mesenchymal cells. There
is a considerable body of research implicating abnormal function of
the aIIbb3 integrin
on platelets and avb3
integrin on vascular smooth muscle cells in thrombosis, atherosclerosis
and restenosis. My research currently focuses on the functional implications
of the PLA polymorphism (PLA1 and PLA2) of the b3
integrin.
Recent Publications:
1. Sajid M, Hu Z, Guo H, Li H, Stouffer GA. Vascular expression of integrin-associated
protein and thrombospondin increase following
mechanical injury. Journal of Investigative Medicine (in press).
2. Lele M, Sajid M, Wajih N, Stouffer GA. Eptifibatide and 7e3, but
not Tirofiban, inhibit alpha v beta 3 integrin-mediated binding of
smooth muscle cells to thrombospondin and prothrombin. Circulation
(in press).
3. Sajid M, Lele M, Stouffer GA. Autocrine thrombospondin partially
mediates TGFb1-induced proliferation of
vascular smooth muscle cells. American Journal of Physiology Heart
& Circulatory Physiology, Vol. 279: H2159-2165, November 2000.
4. Sajid M, Hu Z, Lele M, Stouffer GA. Protein complexes involving
avb3 integrins,
nonmuscle myosin heavy chain-A and focal adhesion kinase form in thrombospondin-treated
smooth muscle cells. Journal of Investigative Medicine, Vol.
48, No.3, May 2000 (190-197).
5. Stouffer GA, Hu Z, Sajid M, Li H, Jin G, Nakada MT, Hanson SR,
Runge MS. b3 integrins are upregulated
after vascular injury and modulate thrombospondin- and thrombin-induced
proliferation of cultured smooth muscle cells. Circulation,
Vol. 97, No. 9, March 10, 1988 (907-915).
 ©1995-99
Baylor College of Medicine
Email: karam@bcm.tmc.edu
URL: http://public.bcm.tmc.edu/medicine/sajid.htm (Modified: May-8-2001)
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