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Thrombosis Research Section Faculty
Faculty (Secondary Appointment)
Research Interests:
Dr. Lawrence Rice is Professor of Medicine in Hematology and Thrombosis
Research. He has been Program Director of Hematology training at Baylor
for 17 years, and director of the Hematology/Oncology course required
of all sophomore medical students for more than twenty years. He has
a very heavy general hematology clinical practice based at the Methodist
Hospital where he is the Hematology service chief. He has won numerous
awards for teaching excellence and is named in several guides to America's
top doctors. His research interests are in thrombocytopenias, particularly
heparin-Induced thrombocytopenia, but also thrombotic thrombocytopenic
purpura and immune thrombocytopenia. He also has interests in newly
discovered actions of erythropoietin in controlling red cell mass
and preventing neocytolysis, the selective hemolysis of young red
blood cells, and interests in iron metabolism and anemias.
Selected Publications:
1. Srinivasan AF, Rice L, Bartholomew JR, Rangaswamy C, La Perna
L, Thompson JE, Murphy S, Baker KR. Warfarin-induced skin necrosis
and venous limb gangrene in the setting of heparin-induced thrombocytopenia.
Arch Intern Med 2003, in press.
2. Kodityal S, Manhas AH, Udden M and Rice L. Danaparoid for heparin-induced
thrombocytopenia: an analysis of treatment failures. Eur J Haematol,
in press, 2003.
3. Rice L and Popat U. Hemolytic anemias. In: D Goldmann, ed. PIER
on-line textbook of medicine. acponline.org, in press, 2003.
4 . Rice L, Nguyen P, and Vann A. Preventing complications in heparin-induced
thrombocytopenia: Alternative anticoagulants are improving patient
outcomes. Post Graduate Medicine 2002;112:85-89.
5. Rice L, Attisha W, Francis JL and Drexler AJ. Delayed onset heparin-induced
thrombocytopenia. Ann Intern Med 2002;36:210-215.
6. Rice L, Nichol JL, McMillan R, Delavari M, Roskos L and Bacile
MH. "Cyclic thrombocytopenia with therapy-responsive thrombopoietin
deficiency." Amer J Hematol 2001;68:210-214.
7 . Trial J, Rice L, and Alfrey CP. Erythropoietin withdrawal alters
interactions between young red cells, splenic endothelial cells, and
macrophages: An in vitro model of neocytolysis. J Invest Med,
2001;49:335-345.
8. Rice L, Ruiz W, Driscoll T, Whitley C, Tapia R, Hachey DL, Gonzales
G and Alfrey CP. Neocytolysis on descent from altitude: A newly recognized
mechanism for the control of red cell mass. Ann Intern Med,
2001;134:652-6.
9. Tsai HM, Rice L, Sarode R, Chow TW and Moake JL. Antibody inhibitors
to von Willebrand factor metalloproteinase and increased von Willebrand
Factor¾Platelet binding in ticlopidine-associated thrombotic
thrombocytopenic purpura. Ann of Intern Med, 2000;132:794-799.
10. Chow TW, Turner NA, Chintagumpala M, McPherson PD, Nolasco LH,
Rice, L, Hellums D, and Moake JL. Increased von Willebrand factor
binding to platelets in single episode and recurrent types of thrombotic
thrombocytopenic purpura. Amer J Hematol 1998;57: 292-302.
11. Alfrey CP, Rice L, Udden M, and Driscoll T. Neocytolysis: A physiologic
down-regulator of red blood cell mass. Lancet 1997;349:1389.
12. Kim SW, Rice L and McCarthy JJ: “Efficacy of Danazol with
autoimmune thrombocytopenia.” Clin Appl Thrombosis/Hemostasis
1997;3:251.
 ©1995-2003
Baylor College of Medicine
Email: medicine@bcm.tmc.edu
URL: http://public.bcm.tmc.edu/medicine/rice.htm (Modified: June 10, 2003)
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