David B. Corry, M.D.
Associate Professor
Departments of Medicine-Pulmonary and Immunology
Research Interest
Dr. Corry's research is focused on immune mechanisms of lung disease. Research projects have included defining critical roles played by CD4+ T cells in lung inflammation and describing the distinct contributions of the cytokines IL-4 and IL-13 in the immunopathogenesis of experimental allergic airway disease. More recently, Dr. Corry’s laboratory has made fundamental discoveries on the role of integrins in T cell function and the role of innate immunity in controlling allergic lung disease, focusing specifically on the roles of exogenous proteinases and fungi as allergens and airway epithelial derived cytokines and proteinases such as IL-25 and matrix metalloproteinase 7. Other current projects include defining IL-4 and IL-13 signaling pathways in the murine lung, elucidating the role of exogenous and endogenous proteinases in Th2 cell differentiation and airway inflammation and defining the homing mechanisms of T cells. Most recently, Dr. Corry’s laboratory has begun to study human microRNAs in lung and peripheral blood T cells focusing on the role that these short transcripts play in orchestrating disease and predicting disease phenotypes in healthy smokers. Similar microRNA projects are focused on mouse lung and the experimental model of asthma.
Selected Publications
Lee, S.-H., Prince, J. E., Rais, M., Kheradmand, F., Ballantyne, C. M., Weitz-Schmidt, G., Smith, C. W., and Corry, D. B. (2008). Developmental control of integrin expression regulates Th2 effector homing. J Immunol 180, 4656-4667.
Kiss, A., Montes, M., Susarla, S., Jaensson, E. A., Drouin, S. M., Wetsel, R. A., Yao, Z., Martin, R., Hamzeh, N., Adelagun, R., et al. (2007). A new mechanism regulating the initiation of allergic airway inflammation. J Allergy Clin Immunol 120, 334-342.
Lee, S.-H., Goswami, S., Grudo, A., Song, L.-Z., Bandi, V., Goodnight-White, S., Green, L., Hacken-Bitar, J., Huh, J., Bakaeen, F., et al. (2007). Antielastin autoimmunity in tobacco smoking-induced emphysema. Nat Med 13, 567-569.
Greenlee, K. J., Corry, D. B., Engler, D. A., Matsunami, R. K., Tessier, P., Cook, R. G., Werb, Z., and Kheradmand, F. (2006). Proteomic identification of in vivo substrates for matrix metalloproteinases 2 and 9 reveals a mechanism for resolution of inflammation. J Immunol 177, 7312-7321.
Grumelli, S., Corry, D. B., Song, L. Z., Song, L., Green, L., Huh, J., Hacken, J., Espada, R., Bag, R., Lewis, D. E., and Kheradmand, F. (2004). An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema. PLoS Med 1, 75-83.
Lee, S. H., Prince, J. E., Rais, M., Kheradmand, F., Shardonofsky, F., Lu, H., Beaudet, A. L., Smith, C. W., Soong, L., and Corry, D. B. (2003). Differential requirement for CD18 in T-helper effector homing. Nat Med 9, 1281-1286.
Corry, D. B., Rishi, K., Kanellis, J., Kiss, A., Song Lz, L. Z., Xu, J., Feng, L., Werb, Z., and Kheradmand, F. (2002). Decreased allergic lung inflammatory cell egression and increased susceptibility to asphyxiation in MMP2-deficiency. Nat Immunol 3, 347-353.
Kheradmand, F., Kiss, A., Xu, J., Lee, S. H., Kolattukudy, P. E., and Corry, D. B. (2002). A protease-activated pathway underlying Th cell type 2 activation and allergic lung disease. J Immunol 169, 5904-5911.
Corry, D. B., and Kheradmand, F. (1999). Induction and regulation of the IgE response. Nature 402, B18-23.
Grunig, G., Warnock, M., Wakil, A. E., Venkayya, R., Brombacher, F., Rennick, D. M., Sheppard, D., Mohrs, M., Donaldson, D. D., Locksley, R. M., and Corry, D. B. (1998). Requirement for IL-13 independently of IL-4 in experimental asthma. Science 282, 2261-2263.
Contact Information
Phone: 713-798-8740
E-mail: dcorry@bcm.edu