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Thrombosis Research Section Faculty
Faculty (Secondary Appointment)
Research Interests:
Dr. Moake is Professor of Medicine at
Baylor College of Medicine and Associate Director of the J.W. Cox
Laboratory for Biomedical Engineering at Rice University. Dr. Moake
is a nationally prominent clinical investigator in hemostasis and
thrombosis. His seminal contributions include the discovery of ultra-large
(UL) multimers of von Willebrand factor (VWF) in the pathophysiology
of thrombotic microangiopathies, including the description of ULVWF
multimers in the plasmas of patients with chronic relapsing TTP and
the demonstration that these patients have a defect in ULVWF processing.
He also was among the first to describe platelet aggregation by shear
stress and to elucidate the mechanisms of this phenomenon. Dr. Moake
is an elected member of the American Society of Clinical Investigation
and the Association of American Physicians. His laboratory focus is
on the basic mechanisms of plasma VWF-cleaving metalloprotease (ADAMTS-13)
interaction with ULVWF multimers emerging from endothelial cells.
ADAMTS-13 activity is deficient in thrombotic thrombocytopenic purpura
(TTP).
Selected Publications:
1. Moake JL: Mechanisms of Disease-Thrombotic thrombocytopenic purpura
and the hemolytic uremic syndrome. New Engl J Med 347:589,
2002.
2. Dong J-f, Nolasco L, Arceneaux W, Shrimpton CN, Schade AJ, Fujikawa
K, McIntire LV, Moake JL, López JA: Rapid cleavage of endothelium-derived
ultra-large von Willebrand factor multimers on the endothelial surface
under fluid shear stress. Blood 100: 4033, 2002.
3. Arya M, Anvari B, Romo GM, Cruz MA, Dong J-F, Mc Intire LV, Moake
JL, Lopez, JA: Ultra-large multimers of von Willebrand factor form
spontaneous high-strength bonds with the platelet GP Ib-IX complex:
studies using optical tweezers. Blood 99:3971, 2002.
4. Moake JL: Thrombotic thrombocytopenic purpura: the systemic platelet
clumping "plague." Ann Rev Med 53:75, 2001.
5. Turner NA, Moake JL, McIntire LV: Blockade of adenosine diphosphate
receptors P2Y12 and P2Y1 is required to inhibit platelet aggregation
in whole blood under flow. Blood 98: 3340, 2001.
6. Bennett CL, Connors JM, Carwile JM, Moake JL, et al.: Thrombotic
thrombocytopenic purpura in patients with clopidogrel. New Engl
J Med 342:1773, 2000.
7. Moake JL,Turner NA, Stathopoulos NA, Nolasco LH, Hellums JD: Involvement
of large plasma von Willebrand factor (vWF) multimers and unusually
large vWF forms derived from endothelial cells in shear stress-induced
platelet aggregation. J Clin Invest 78:1456, 1986.
8. Moake JL, Rudy CK,Troll JH, Weinstein MJ, Colannino NM, Azocar
J, Seder RH, Hong SL, Deykin D: Unusually large plasma factor VIII:von
Willebrand factor multimers in chronic relapsing thrombotic thrombocytopenic
purpura. N Engl J Med 307:1432, 1982.
 ©1995-2003
Baylor College of Medicine
Email: medicine@bcm.tmc.edu
URL: http://public.bcm.tmc.edu/medicine/moake.html
(Modified:
June 3, 2003
)
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