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Thrombosis Research Section Faculty
Faculty (Secondary Appointment)
Research Interests:
Dr. McIntire's research is focused on understanding the interplay
between fluid mechanics, convective mass transport, cell biology,
and molecular biology in the cardiovascular system. By combining videomicroscopy
of model blood vessels with digital image processing, Professor McIntire
and his research group are making substantial progress in understanding
the molecular basis of the complex, highly regulated mechanisms by
which leukocytes and white blood cells migrate through the endothelial
cell monolayer. The goal of this research is to learn how to enhance
the body's immune response and to control cancer metastasis. Dr. McIntire
and his group have also demonstrated selective flow regulation of
secretion and messenger RNA levels in endothelial cells for several
proteins and peptides. They are seeking knowledge of the control mechanism
at the DNA level, with the goal of identifying stress-sensitive gene-promoter
elements. Dr. McIntire is a founding fellow and past President of
the American Institute of Medical and Biological Engineering, a fellow
of the American Institute of Chemical Engineering, and a fellow of
the American Association for the Advancement of Science.
Recent References:
1. Fredrickson, B.J., Turner, N.A., Kleiman, N.S., Maresh, K., Mascelli,
M.A., Effvon, M.B., and McIntire, L.V., "Effects of Abciximab,
Ticlopidine and Combined Abciximab/Ticlopidine Therapy on Platelet
and Leukocyte Function in Patients Undergoing Coronary Angioplasty",
Circulation 2000;101:1122-1129.
2. Shiu, Y-T., Udden, M.M., and McIntire, L.V., “Perfusion
with Sickle Erythrocytes Upregulates ICAM-1 and VCAM-1 Gene Expression
in Cultured Human Endothelial Cells”, Blood 2000;95:3232-3241.
3. McCormick, S.M., Whitson, P.A., Wu, K.K. and McIntire, L.V., “Shear
Stress Differentially Regulates PGHS-1 and PGHS-2 Protein Levels in
Human Endothelial Cells”, Annals of Biomedical Engineering
2000; 28: 824-833.
4. Nguyen, K.T., Patterson, C., Eskin, S.G., Runge, M.S., and McIntire,
L.V., “Arterial Shear Stress Reduces Protease Activated Receptor-1
Expression and Attenuates Response to Thrombin in Endothelial Cells”,
Annals of Biomedical Engineering 2001;29:145-153.
5. Turner, N., Moake, J.L., and McIntire, L.V., "Blockade of
Both ADP Receptors, P2Y12 and P2Y1, is Required to Inhibit Platelet
Aggregation in Whole Blood Under Flow", Blood 2001;98:3340-3345.
6. Li, F., Moake, J.L. and McIntire, L.V., "Characterization
of von Willebrand Interaction with Collagens Using Surface Plasmon
Resonance", Ann. Biomed. Eng. 2002;30:1107-1116.
7. Kukreti, S., Smith, C.W., and McIntire, L.V., "Differential
Roles of VCAM-1 and P-selection in Mediating Monocyte Adhesion Under
Dynamic Flow Conditions", accepted for publication in J.
Leukocyte Biol. (2002).
8. McCormick, S.M., Frye, S.R., Eskin, S.G., Teng, C.L., Lu, C-M.,
Russell, C.G., Chittur, K.K., McIntire, L.V., “Microarray Analysis
of Shear Stressed Endothelial Cells” , Biorheology
2003;40:5-11.
9. Kao, S-H., Turner, N.A., Moake, J.L., and McIntire, L. V., “A
Novel Flow Cytometric Analysis for Platelet Activation on Immobilized
von Willebrand Factor or Fibrillar Collagen”, J. of Thrombosis
and Haemostasis 2003;1:347-354.
 ©1995-2003
Baylor College of Medicine
Email: medicine@bcm.tmc.edu
URL: http://public.bcm.tmc.edu/medicine/mcintire.html (Modified: June 4, 2003 )
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