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Thrombosis Research Section Faculty
Full-Time Faculty (Primary Appointment)
Research Interests:
Coronary heart disease and other vascular diseases account
for approximately half of all deaths in women. Although the underlying
pathophysiological processes are similar, the onset and clinical end-points
of women are significantly delayed compared to men. My current research
interests include the gender differences in the development of thrombotic
diseases and the mechanisms of arterial thrombosis in women. My major
effort is focused on the gender differences in platelet function and
sex hormone regulation of megakaryocytes function. Studies have been
initiated to isolate and identify megakaryocyte cDNAs in response
to sex hormones.
Recent Publications:
1. Leng, X.H., Tsuyoshi, N. and Forgac, M. (1999) Transmembrane Topography
of the 100-kDa a Subunit (Vph1p) of the Yeast Vacuolar Proton-Translocating
ATPase. J Biol Chem 274(21): 14655-61.
2. Leng, X.H., Manolson, M. and Forgac, M. (1998) Function of the
C-terminal Domain of Vph1p in Activity and Assembly of the Yeast V-ATPase.
J Biol Chem 273(12): 6717-23.
3. Dillon, J.S., Wheeler, M.B., Leng, X.H., Ligon, B.B., and Boyd,
A.E. 3rd. (1997) The Cloning and Functional Expression Human Glucagon-Like
Peptide-1 (GLP-1) Receptor. Adv Exp Med Biol 426:113-9
4. Liu, Q., Leng, X.H., Newman, P.R., Vasilyeva, E., Kane, P.M. and
Forgac, M. (1997) Site-directed mutagenesis of the yeast V-ATPase
A subunit. J.Biol.Chem. 272(18): 11750-63.
5. Leng, X.H., Manolson, M., Liu, Q. and Forgac, M. (1996) Site-directed
mutagenesis of the 100 kDa subunit (Vph1p) of the yeast vacuolar (H+)
-ATPase. J Biol Chem 271(37): 22487-22493.
6. Lu, M., Wheeler, M.B., Leng, X.H., and Boyd, III, A.E. (1994)
Stimulation of insulin secretion and insulin gene expression by gastric
inhibitory polypeptide. Transact Assoc Amer Physicians 106:
42-53.
7. Wheeler, M.B., Lu, M., Dillon, J., Leng, X.H., Chen, C., and Boyd,
III, A.E (1993) Functional expression of the glucagon-like 1 (7-37)
receptor: evidence for the coupling to phospholipase C as well as
adenylyl cyclase. Endocrinology, 133(1):57-62.
8. Lu, M., Wheeler, M.B., Leng, X.H., and Boyd, III, A.E. (1993)
The role of free cytosolic calcium in the signal transduction of gastric
inhibitory polypeptide and glucagon-like peptide I(7-37) in beta cells.
Endocrinology, 132:94-100.
 ©Department
of Medicine, Baylor College of Medicine
Email: karam@bcm.tmc.edu
URL: http://public.bcm.tmc.edu/medicine/leng.html
(Modified: July 22, 2002)
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