Basic Science Research
- Dr. Vahid Afshar-Khargan
Identification of new functional polymorphisms in platelet and neutrophil receptors.
- Dr. Malcolm Brenner
Gene transfer to augment the immune response to human tumors
Effects of CD45 monoclonal antibodies on normal and malignant hemopoiesis.
- Dr. Paul Bray
Correlating platelet polymorphisms with platelet function and clinical events.
Testing the effects of sex hormones on platelet function.
Cloning megakaryocyte genes regulated by sex hormones.
Characterizing the platelet GPIb/IX-GPIIb-IIIa axis.
- Dr. William Durante
Regulation of amino acid transport and metabolism by vascular cells.
The effect of hemodynamic forces on vascular cell function.
Biology of nitric oxide and carbon monoxide in the vessel wall.
- Dr. Si-Yi Chen
Generation of a new class of antigen-specific killer cells.
A novel "intrakine" strategy to modify stem cells or lymphocytes for HIV-1 gene therapy
- Dr. Daniel Epner
GAPDH: Novel regulator of cell structure and migration.
- Dr. Suzanne Fuqua
Hypersensitive estrogen receptor in premalignant breast.
- Dr. Michael Kroll
Mechanisms of von Willebrand factor-induced platelet activation.
The effect of physical forces on platelets.
Functional analyses of glycoprotein Ib/IX/V signaling.
- Dr. José López
Investigating the mechanisms by which platelets interact with components of the vessel wall (subendothelium and endothelium) and with leukocytes.
B iology of the platelet glycoprotein (GP) Ib-IX-V complex.
- Dr. Adrian Lee
IRS-1 and -2 signaling in mammary development and cancer.
Cross-talk between ER and IGF signaling in development and progression of breast cancer.
Targeting cross-talk between ER and IGF signaling as a therapy for breast cancer.
A unique breast cancer cell model for studying reported functions of membrane-localized estrogen receptor alpha.
Progesterone regulation of insulin receptor substrates mediates focal adhesion formation in breast cancer cells.
ER corepressor function of SAFB in breast cancer.
- Dr. Michael Lewis
Developmental biology of the mammary gland as it relates to both normal breast function and breast cancer progression.
Role of hedgehog signal transduction in mammary gland development and breast cancer using the mouse as a model organism.
- Dr. José López
Adhesion of platelets to the blood vessel wall following blood vessel injury.
Biology of the GP Ib-IX-V complex.
- Dr. Steffi Oesterreich
Study of the mechanism by which coregulators affect steroid receptor activities (chromatin remodeling, RNA processing, nuclear matrix association).
Identification of new tumor suppressor genes in breast cancer.
Study of transcription and nuclear organization.
Characterization of steroid receptor cofactors.
- Dr. C. Kent Osborne
Molecular mechanisms for hormonal resistance in breast cancer: growth factor signaling pathways, phosphorylation of estrogen receptor, and interaction with receptor coregulators.
Molecular profiling of breast cancers for the identification of prognostic markers to individualize treatment and for the identification of new molecular targets for prevention and treatment.
Mechanisms of endocrine resistance in breast cancer.
Gene therapy for the prevention and treatment of breast cancer.
- Dr. Josef Prchal
Molecular biology of polycythemia vera.
Molecular biology of primary polycythemia (animal model).
Hypoxia sensing in Chuvash Polycythemia.
Essential Thrombocythemia: in search of the ET gene.
E-mail this page to a friend
