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Thrombosis Research Section Faculty
Full-Time Faculty (Primary Appointment)
Research Interests:
My previous work was on hypercoagulable states in patients with autoimmune
diseases with specific emphasis on the pathophysiology of the antiphospholipid
syndrome. Currently I am interested in the generation of platelet-specific
knockout mice and platelet specific transgenic mice to study the role
of CD40 and CD40L from platelets in inflammatory processes like atherosclerosis.
This efforts may shed light on possible interventions aimed at disrupting
the connections between inflammation and thrombosis.
Selected References:
Gushiken FC, Le A, Arnett FC, Thiagarajan P. Polymorphisms of b2-glycoprotein
I: phospholipid binding and multimeric structure. Throm Res.
2002;108:175-180.
Verma KK, Gushiken FC, Wu KK, Vriesendorp FJ, Dimachkie MM. Calf compartment
syndrome and lumbar plexopathy following topical bovine thrombin-induced
coagulopathy. J Clin Neuromusc Dis. 2001;2:139-141.
Gushiken FC, Arnett FC, Thiagarajan P. Primary antiphospholipid antibody
syndrome with mutations in the phospholipid binding domain of b2-glycoprotein
I. Am J Hematol. 2000;65:160-165.
Gushiken FC, Thiagarajan P, Arnett FC. Polymorphism of b2-glycoprotein
I at codons 306 and 316 in patients with SLE and antiphospholipid
syndrome. Arthritis Rheum. 1999;42:1189-93.
 ©1995-03
Baylor College of Medicine
Email: medicine@bcm.tmc.edu
URL: http://public.bcm.tmc.edu/medicine/gushiken.html (Modified: June 9, 2003)
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