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Thrombosis Research Section Faculty
Full-Time Faculty (Primary Appointment)
Research Interests:
Research in our group has been concentrated on platelet functions
under high fluid shear stress. Our aim is to understand how platelets
interact with subendothelium, with each other, and with other blood
cells under flow condition. We are particularly interested in dissecting
signal pathways that are initiated by the interaction of platelet
glycoprotein Ib-IX-V complex and von Willebrand factor. Our research
also focuses on defining mechanisms through which the endothelium-derived
ultra-large von Willebrand factor multimers are cleaved by the ADAMTS-13
metalloprotease in vivo and what roles of this proteolysis process
may play in the development of thrombosis. Such efforts will allow
us to identify agents that selectively block pathophysiological thrombosis
without affecting physioligcal hemostatic function of platelets.
Recent Publications
1. Shrimpton C.N., Borthakur G, Cruz, M.A., Dong J.F., López
JA. Localization of the adhesion receptor glycoprotein Ib-IX-V complex
to lipid rafts is required for platelet adhesion and activation. J
Exp Med 2002;196(8):1057-66.
2. Zhang, J.N., Bergeron, A. L., Yu, Q., Sun, L. McIntire, L.V., López,
J.A., Dong, J.F. Platelet aggregation and activation under complex
patterns of shear stress. Thromb. Hemost 2002;88(5):817-821.
3. Dong, J.F., Nolasco, L. Arceneaux, W., Shrimpton, C.N. Schade,
A.J., Fujikawa, K., McIntire, L.V., Moake, J.L., López, J.A.
Rapid cleavage of endothelium-derived ultra-large von Willebrand factor
multimers on the endothelial surface under fluid shear stress Blood
2002;100(12):4033-4039.
4. Li, CQ., Dong, J.F., López, JA. The mucin-like macroglycopeptide
region of glycoprotein Iba is required for cell adhesion to immobilized
von Willebrand factor under flow. Thromb. Hemost 2002;88(4):
673-677.
5. Musher, D., Goldsmith, E., Dunbar, S., Tilney, G., Darouiche, R.,
Yu, Q., López, J.A., Dong, J.F. The association between hypercoagulable
states or hyperreactive platelets and bacterial colonization of intravenous
catheters. J Infect Dis. 2002;186(6): 769-773.
6. Garner, SF., Campbell, K., Metcalfe, P., Keidan, J., Dong, J.F.,
López, J.A., Ouwehand, W. Glycoprotein V: the predominant target
antigen in gold-induced autoimmune thrombocytopenia Blood
2002;100(1):344-346.
7. Schade, AJ., Arya, M., Gao, S., Diz-Küçükkaya,
R. Anvari, B., McIntire, L.V., López, JA., and Dong, J.F. Cytoplasmic
truncation of GP Iba weakens its interaction with von Willebrand factor
and impairs cell adhesion. Biochemistry 2003;42(7): 2245-2251.
8. Vijayan K.V., Huang, T.C., Liu, Y. Bernardo, A., Dong, J.F., Moake,
J. Alevriadou, R.B., Goldschmidt-Clermont, P.J., Bray, P.F. Shear
stress augments the enhanced adhesive phenotype of cells expression
the Pro33 isoform of integrin b3. FEBS letter 2003;540:41-46.
9. Chen, J., Dong, J.F., Sun, S., Bergeron, A., McBride, L., Pillai,
M., Barnard, M.R., Salmon, J. Michelson, A.D., Bray, P.F. Platelet
FcgRIIA HIS/ARG131 polymorphism and platelet function: antibodies
to platelet-bound fibrinogen induce platelet activation. J. Thromb.
Hemost 2003;1:355-362.
10. Vijayan,K.V., Liu, Y., Dong, J.F., Bray, P.F. Enhanced Activation
of Mitogen-activated Protein Kinase and Myosin Light Chain Kinase
by the Pro33 Polymorphism of Integrin b3. J. Biol. Chem.
2003;278(6):3860-3867.
 ©1995-2003
Baylor College of Medicine
Email: medicine@bcm.tmc.edu
URL: http://public.bcm.tmc.edu/medicine/dong.html (Modified:
June 3, 2003
)
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