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Thrombosis Research Section Faculty
Faculty (Secondary Appointment)
MICHAEL C. BERNDT, PH.D.
Professor Michael Berndt is currently a NH&MRC Senior Principal
Research Fellow and Associate Director of the Baker Medical Research
Institute, Melbourne, Australia. At Baylor he holds an Adjunct Associate
Professorial appointment in the Thrombosis Research Section, where
he collaborates principally with Jose Lopez and Michael Kroll.
Research Interests:
Dr. Berndt's long-term research interests are in how platelets and
leukocytes interact with the vascular cell wall and how this adhesive
interaction signals subsequent events in thrombosis and inflammation.
These areas have been addressed using classical protein chemistry
and cell biology approaches and more recently by transfection studies
in model cell systems. He has published over 160 papers in the fields
of Thrombosis and Hemostasis and Vascular Biology.
Recent Publications:
1. Dong J-F, Berndt MC, Schade A, McIntire LV, Andrews RK, López
JA. Ristocetin- but not botrocetin-dependent binding of von Willebrand
factor to the platelet membrane glycoprotein Ib-IX-V complex correlates
with shear-dependent interactions. Blood, in press, 2001.
2. De Luca M, Facey DA, Favaloro EJ, Hertzberg MS. Whisstock JC,
McNally T, Andrews RK, Berndt MC. Structure and function of the von
Willebrand Factor A1 domain. Analysis with monoclonal antibodies reveals
distinct binding sites involved in recognition of the platelet membrane
glycoprotein Ib-IX-V complex and ristocetin-dependent activation.
Blood, 95: 164-172, 2000.
3. Feng S, Christodoulides N, Resendiz JC, Berndt MC, Kroll MH. The
cytoplasmic domain of GP Iba and GP Ibb regulates 14-3-3z binding
to GP Ib/IX/V. Blood, 95: 551-557, 2000.
4. Shen Y, Romo G, Dong J-F, Schade A, McIntire LV, Kenny D, Whisstock
JC, Berndt MC, López JA, Andrews RK. Requirement of leucine-rich
repeats of GP Iba for shear-dependent and static binding of von Willebrand
factor to the platelet membrane GP Ib-IX-V complex. Blood,
95: 903-910, 2000.
5. Munday AD, Berndt MC, Mitchell CA. The phosphoinositide 3-kinase
forms a complex with platelet membrane glycoprotein Ib-IX-V complex
and 14-3-3 zeta. Blood, 96:577-584, 2000.
6. Guthridge MA, Stomski FC, Barry EF, Winnall W, Woodcock JM, McClure
BJ, Dottore M, Berndt MC, Lopez AF. Site-specific serine phosphorylation
of the IL-3 receptor is required for hemopoietic cell survival. Molecular
Cell, 66: 99-108, 2000.
7. Simon DI, Chen Z, Xu H, Li CQ, Dong J-F, Ballantyne CM, Zhang
L, Furman MI, Berndt MC, Lopez JA. Platelet glycoprotein Iba is a
counter-receptor for the leukocyte integrin Mac-1 (CD11b/CD18). J
Exp Med, 192: 193-204, 2000.
 ©1995-99
Baylor College of Medicine
Email: karam@bcm.tmc.edu
URL: http://public.bcm.tmc.edu/medicine/berndt.html (Modified: Feb-22-2001)
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