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Thrombosis Research Section Faculty
Full-Time Faculty (Primary Appointment)
Research Interest:
One of my research interests is to identify new functional polymorphisms
in the platelet and neutrophil receptors. My goal is to translate
the knowledge obtained by basic research in this field to the information
applicable in prevention and treatment of thrombotic disease. I am
also interested in studying the molecular basis and physiologic consequences
of interaction between platelets and complement system. Research in
this field is important in better understanding of the connection
between thrombosis and inflammation.
Recent Publications:
1. Afshar-Kharghan V, Matijevic-Aleksic N, Ahn C, Boerwinkle E, Wu
KK, and López JA: The Variable Number of Tandem Repeat Polymorphism
of Platelet Glycoprotein Iba and Risk of
Coronary Heart Disease (submitted).
2. Afshar-Kharghan V, Diz-Küçükkaya R, Ludwig EH,
Marian AJ, and López JA: Human polymorphism of P-selectin glycoprotein
ligand 1 attributable to variable numbers of tandem decameric repeats
in the mucinlike region, Blood, 15 May 2001, 97(10): 3306-3307
3. Baker RI, Eikelboom J, Lofthouse E, Staples N, Afshar-Kharghan
V, Lopez JA, Shen Y, Berndt MC, and Hankey G: Platelet glycoprotein
Iba Kozak polymorphism is associated with
an increased risk of ischemic stroke, Blood, 1 July 2001, 98(1):
36-40.
4. Afshar-Kharghan V, Sae-Tung G, Li CQ, Sun L, Dong JF, López
JA: Necessity of conserved residues in the leucine-rich repeats of
glycoprotein Iba for proper conformation
and stability of the ligand-binding region. Biochemistry, March
28, 2000, 39(12): 3384-91.
5. Afshar-Kharghan V, López JA: Bernard-Soulier syndrome in
a patient doubly heterozygous for two frame shift mutations in the
Glycoprotein Iba gene. British Journal
of Haematology, 2000, 110: 919-924.
6. Afshar-Kharghan V, Khoshnevis-Asl M, López JA: Kozak sequence
polymorphism is a major determinant of the surface levels of a platelet
adhesion receptor. Blood, July 1, 1999, 94(1): 186-191.
7. Afshar-Kharghan V, López JA: Bernard-Soulier syndrome caused
by a dinucleotide deletion and reading frame shift in the region encoding
the glycoprotein Iba transmembrane domain.
Blood, October 1, 1997, 90(7): 2634-2643.
8. Sachs UJH, Kiefel V, Böhringer M, Afshar-Kharghan V, Kroll
H, and Santoso S: Single amino acid substitution in human platelet
Glycoprotein Ibb is responsible for the
formation of the platelet-specific alloantigen Iya. Blood,
March 1, 2000, 95(5): 1849-55.
9. López JA, Andrews RK, Afshar-Kharghan V, Berndt MC: Review:
Bernard-Soulier Syndrome. Blood, June 15, 1998, 91(12): 4397-4418.
10. Dong JF, Li CQ, Sae-Tung G, Hyun W, Afshar-Kharghan V, López
J A: The cytoplasmic domain of glycoprotein(GP) Iba
constrains the lateral diffusion of the GP Ib-IX complex and modulates
von Willebrand Factor binding. Biochemistry, October 14, 1997,
36(41): 12421-12427.
 ©1995-2003
Baylor College of Medicine
Email: medicine@bcm.tmc.edu
URL: http://public.bcm.tmc.edu/medicine/afsharkharghan.htm (Modified:
June 23, 2003)
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