Adriano Flora, Ph.D., Post-doc

Phone: 713-798-6695
E-mail: aflora@bcm.edu

Joined the lab: July 2002

Education:
March 1996: Graduation in Biology cum laude, University of Milano.
November 2001: Ph.D. in Pharmacology and Toxicology.

Project: Definition of the role of the bHLH transcription factor Math1 in neuronal development.

The aim of the project is to define the function of the transcription factor Math1 in the development of the central nervous system by:

• identifying the molecular mechanisms underlying the transcriptional activity of Math1.
• finding the target genes of Math1 in order to reveal the transcriptional network that regulate neural progenitor proliferation and differentiation.
• using transgenic mice to validate in vitro discoveries in in vivo models of neuronal development.

Selected publications:
Cargnin F, Flora A, Di Lascio S, Battaglioli E, Longhi R, Clementi F, Fornasari D. PHOX2B regulates its own expression by a transcriptional auto-regulatory mechanism. J Biol Chem. 2005, Nov. 11;280(45):37439-48.

Flora A., Lucchetti H, Benfante R, Goridis C., Clementi F, and Fornasari D. SP proteins and PHOX2B regulate the expression of the human PHOX2a gene. J Neurosci. 2001, 21(18): 7037-7045.

Flora A., Schulz R., Benfante R., Battaglioli E., Terzano S., Clementi F., Fornasari D. Neuronal and extra-neuronal regulation of the expression of the human alpha5 nicotinic receptor subunit gene. J Neurochem. 2000, 75: 18-27.