Assistant Professor, Departments of Molecular and Human Genetics

B.S., Mathematics, Duke University, 1995
Ph.D., Mathematical Statistics, Rice University, 2001

RESEARCH INTERESTS:

My main research interests are systems biology and the analysis of large scale genomic data. My laboratory has done extensive research in the use of genomic annotations to enhance analysis of microarray experiments. We have developed a variety of web-based software including tools for Gene Ontology analysis as well as an interactive system for exploration of protein-protein interaction networks. We have also developed tools for web-based visualization and sharing of gene expression data. We analyze primary microarray data sets from all array platforms including expression arrays, genome content arrays (aCGH), microRNA arrays, and chromatin arrays with an expertise in data pre-processing and normalization. Our methodological work involves statistical considerations for use of annotations in analysis of very large scale genomic data.

SELECTED PUBLICATIONS:

1. Probst FJ, Roeder ER, Enciso VB, Ou Z, Cooper ML, Eng P, Li J, Gu Y, Stratton RF, Chinault AC, Shaw CA, Sutton VR, Cheung SW, Nelson DL (2007). Chromosomal microarray analysis (CMA) detects a large X chromosome deletion including FMR1, FMR2, and IDS in a female patient with mental retardation. Am. J. Med. Genet. A. 143: 1358-1365.

2. Sahoo T, Bacino CA, German JR, Shaw CA, Bird LM, Kimonis V, Anselm I, Waisbren S, Beaudet AL, Peters SU (2007). Identification of novel deletions of 15q11q13 in Angelman syndrome by array-CGH: molecular characterization and genotype-phenotype correlations. Eur. J. Hum. Genet. 15: 943-949.

3. Lu X, Shaw CA, Patel A, Li J, Cooper ML, Wells WR, Sullivan CM, Sahoo T, Yatsenko SA, Bacino CA, Stankiewicz P, Ou Z, Chinault AC, Beaudet AL, Lupski JR, Cheung SW, Ward PA (2007). Clinical implementation of chromosomal microarray analysis: summary of 2513 postnatal cases. PLoS ONE. 2: e327.

4. Sahoo T, Cheung SW, Ward P, Darilek S, Patel A, del Gaudio D, Kang SH, Lalani SR, Li J, McAdoo S, Burke A, Shaw CA, Stankiewicz P, Chinault AC, Van den Veyver IB, Roa BB, Beaudet AL, Eng CM (2006). Prenatal diagnosis of chromosomal abnormalities using array-based comparative genomic hybridization. Genet. Med. 8: 719-727.

5. Lim J, Hao T, Shaw C, Patel AJ, Szabo G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabasi AL, Vidal M, Zoghbi HY (2006). A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Cell 125: 801-814.

6. Cheung SW, Shaw CA, Yu W, Li J, Ou Z, Patel A, Yatsenko SA, Cooper ML, Furman P, Stankiewicz P, Lupski JR, Chinault AC, Beaudet AL (2005). Development and validation of a CGH microarray for clinical cytogenetic diagnosis. Genet. Med. 7: 422-432. Erratum in: Genet Med. 2005 7: 478.

7. Shaw CJ, Shaw CA, Yu W, Stankiewicz P, White LD, Beaudet AL, Lupski JR (2004). Comparative genomic hybridisation using a proximal 17p BAC/PAC array detects rearrangements responsible for four genomic disorders. J. Med. Genet. 41: 113-119.

8. Venezia TA, Merchant AA, Ramos CA, Whitehouse NL, Young AS, Shaw CA, Goodell MA (2004). Molecular signatures of proliferation and quiescence in hematopoietic stem cells. PLoS Biol. 2: e301.

9. Young A, Whitehouse N, Cho J, Shaw C (2005). OntologyTraverser: an R package for GO analysis. Bioinformatics 21: 275-276.

For more publications, see listing on Pub Med.

CONTACT INFORMATION:

Chad Shaw, Ph.D.
Department of Molecular and Human Genetics
Baylor College of Medicine
One Baylor Plaza, Rm. 333C
Houston, Texas 77030, USA
Mail Stop: BCM225

Office: 713-798-8087
E-mail:
Web site: http://franklin.imgen.bcm.tmc.edu

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