Professor, Departments of Pediatrics and Molecular and Human Genetics; Programs in Cell & Molecular Biology and Developmental Biology; Center for Cell and Gene Therapy

B.S., Imperial College of Science and Technology, London, England, 1986
Ph.D., Cambridge University, Cambridge, England, 1991
Postdoc, Whitehead Institute, Massachusetts Institute of Technology, 1996
Postdoc, Harvard Medical School, 1997

RESEARCH INTERESTS:

Hematopoietic Stem Cell Biology

We are interested in the basic biology of hematopoietic stem cells. It has been known for decades that hematopoietic stem cells reside in the bone marrow in a quiescent state and replenish the supply of differentiated cells of the peripheral blood throughout the lifetime of an animal. No other adult cell type retains the capacity for such immense proliferation and differentiation. However, little is known about the cells or factors that regulate their primitive state or control their activiation. We study the behavior of these stem cells in vivo and in vitro using mouse stem cells as a model, as well as pursue the mechanisms which controls their behavior on a molecular level using micoarray technology and mouse mutants.

SELECTED PUBLICATIONS:

1. Feng CG, Weksberg DC, Taylor GA, Sher A, Goodell MA (2008). The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation. Cell Stem Cell 2: 83-89.

2. Weksberg DC, Chambers SM, Boles NC, Goodell MA (2008). CD150- side population cells represent a functionally distinct population of long-term hematopoietic stem cells. Blood 111: 2444-2451.

3. Chambers SM, Boles NC, Lin KY, Tierney MP, Bowman TV, Bradfute SB, Chen AJ, Merchant AA, Sirin O, Weksberg DC, Merchant MG, Fisk CJ, Shaw CA, Goodell MA (2007). Hematopoietic Fingerprints: An Expression Database of Stem Cells and Their Progeny. Cell Stem Cell 1: 578-591.

4. Chambers SM, Shaw CA, Gatza C, Fisk CJ, Donehower LA, Goodell MA (2007). Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation. PLoS Biol. 5: e201.

For more publications, see listing on Pub Med.

CONTACT INFORMATION:

Margaret A. Goodell, Ph.D.
Assistant Professor
Center for Cell and Gene Therapy
One Baylor Plaza, Room N1030
Baylor College of Medicine
Houston, TX 77030

Phone: 713-798-1265
Laboratory: 713-798-1271
Fax: 713-798-1230
E-mail:
Web site: http://www.bcm.edu/labs/goodell/

Administrative Assistant: Amy Lakin
E-mail:
Phone: 713-798-1246

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