The Kleberg Cytogenetics Laboratory offers a fluorescence in situ hybridization (FISH)-based assay of prenatal specimens (either amniotic fluid or CVS) for detecting numerical abnormalities of chromosomes 13, 18, 21, X and Y. Reasons for Referral:Prenatal aneuploidy screening by FISH can be performed on patients in need of rapid preliminary results due to an abnormal ultrasound examination or advanced gestational age. All FISH results are followed by a routine cytogenetic analysis and not considered final until the karyotypes are completed. A normal aneuploidy screen does not rule out mosaicism for aneuploidy, structural rearrangements or deletions of chromosomes. Testing Methodology:FISH is the application of fluorescently labeled DNA molecules to metaphase chromosomes and interphase nuclei for the detection of chromosome abnormalities and alterations. The aneuploidy FISH analysis is performed on interphase nuclei. A result is considered interpretable if hybridization is consistent in at least 70% of cells examined. Our aneuploidy screen is rapid and reliable. Results are available within 24 to 48 hours from receipt of the sample. Please note: Chromosome analysis is required on every patient sample referred for aneuploidy screening by FISH. Additional cost will be incurred for chromosome analysis. Specimen Requirements:Amnio: 20-30
cc of direct fluid (Discard the first 2cc collected) Shipping and Handling:All tubes must be labeled with the patient's name and date of birth, and a completed requisition form must accompany each sample. If the laboratory is billing the patient's insurance, please enclose a copy of the insurance card. Ship specimens for overnight delivery at ambient temperature. Please notify the laboratory of incoming samples. Turnaround Time:FISH results: 1-2
days CPT Codes and Prices:88271x5, 88275, 88291, 99050 Forms:>> Cytogenetics Requisition Test Codes:8410 |