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Jason Shohet, MD, PhD
Education:
Department of Pediatrics
Section of Hematology-Oncology,
Baylor College of Medicine
Contact Information:
jmshohet@texaschildrenshospital.org
832-824-4735
1985 BA Chemistry Reed College, Portland, OR
1993 M.D., Ph.D. Boston University School of Medicine, Boston, Mass.
Research Interests:
My current research interests involve the molecular characterization
of pediatric tumors with the aim of developing molecularly targeted
therapies. The MYC oncogenes are transcription factors which influence
a wide variety of cellular processes including cell cycle regulation,
angiogenesis and chromosomal stability. Using microarray gene expression
profiling and subtractive hybridization we have identified a series
of genes regulated by MYCN in neuroblastoma. The further characterization
of the role of these genes in MYCN driven tumorigenesis is a major focus
of the lab. Currently we are using SiRNA post-transcriptional silencing,
chromatin immunoprecipitation assays, and conditional cell lines to
study the impact of MYCN target molecules on tumor cell growth and metastasis.
We are also developing transgenic mouse models to study the pathological
consequences of disrupted regulation of selected MYCN target genes.
Selected Publications:
Shohet, J.M., Bergemascini, L., Davis, A.E., Carroll, M.C.
Localization of the covalent binding site of complement protein C3 on
the IgG heavy chain. Journal of Biological Chemistry, 266:28, 18520-24,
1991.
Shohet, J.M., Pemberton, P., Carroll, M.C. Identification of a major
binding site for complement C3 on the IgG heavy chain. Journal of Biological
Chemistry, 268, 5866-71, 1993.
Shohet, J.M., Frazer, K, Banchereau, J.B., Capra, J.D., Pascual, M.V.,
Isolation and characterization of RP5: a novel tandem C2 domain protein
expressed in germinal center B cells. Submitted JBC , 2001.
Shohet,J.M., Hicks, M.J,, Plon, S.E., Susan Stuart, Si-Yi Chen, Malcolm
Brenner and Jed G. Nuchtern, Minichromosome Maintenance Protein MCM7
is a Direct Target of the MYCN transcription Factor in Neuroblastoma.
Cancer Research, 62, 1123-1128, Feb 15 , 2002.
©2002,
Cell And Gene Therapy, Baylor College
of Medicine
One Baylor Plaza, N1002, Houston, TX 77030, (713)798-1246
URL: http://www.bcm.edu/genetherapy
Email:cagt@bcm.edu
(Modified:August 15, 2006- SM)
