Barbara Savoldo, MD

Assistant Professor Department of Pediatrics Section of Hematology-Oncology Center for Cell and Gene Therapy, Baylor College of Medicine

 

 

 

Contact Information:
bsavoldo@bcm.edu
832-824-4725

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Education:
M.D., University of Parma, Italy
Fellow, Department of Hematology, University of Parma, Italy
Postdoctoral Fellow, Center for Cell and Gene Therapy

Research Interests:
Dr. Savoldo’s research interest is in the development of in immunotherapy strategies for virus-associated malignancies and diseases. In collaboration with Dr Rooney, Dr Heslop and Dr Brenner, she has developed protocols for treatment of EBV-lymphoma developing in recipients of solid organ transplant and of Chronic active EBV infection. In the research laboratory, Dr Savoldo is developing assays for early identification of patients at risk for developing EBV-associated diseases. She is also working on the development of immuno-therapeutic strategies for treatment of non EBV-related Hodgkin Lymphoma and on improving function and persistence of chimeric T cells.

Selected Publications:

Savoldo B, Goss J, L Liu, et al. Generation of autologous Epstein Barr Virus (EBV)-specific cytotoxic T cells (CTL) for adoptive immunotherapy in solid organ transplant recipients. Transplantation, 72: 1078-86, 2001.

Savoldo B, Cubbage M, Durett A, et al. Generation of autologous Epstein-Barr virus (EBV)-specific CD(4+)cytotoxic T cells (CTL) from naive individuals. J. Immunol, 168:909-18, 2002.

Savoldo B, Huls MH, Volk HD, et al. Autologous Epstein-Barr virus (EBV)-specific cytotoxic T cells for the treatment of Chronic Active EBV infection syndrome. Blood. 100:4059, 2002 .

Straathof KCM, Savoldo B, Heslop HE, Rooney CM. Immunotherapyfor post transplant lymphoproliferative disease. Br J Haematology, 118:728, 2002

Dotti G, Savoldo B, Yotnda P, Rill D, Brenner MK. Transgenic expression of CD40-ligand (CD40L) produces an in vivo antitumor immune response to both CD40 positive and negative plasmacytoma cells. Blood, 100:200, 2002.

Leen AM, Sili U, Savoldo B, et al. Fiber-modified adenoviruses generate sub-group cross-reactive, adenovirus-specific cytotoxic T lymphocytes for therapeutic applications. Blood 103:1011, 2004.

Yotnda PN, Savoldo B, Charlet-Berguerand N, et al. Targeted delivery of adenoviral vectors by cytotoxic T cells. Blood. 104:2272, 2004.

Savoldo B, Rooney CM, Quiros-Tejeira RE , et al. Immunity To Epstein-Barr Virus In Liver Transplant Recipients Treated With Rituximab For Post-Transplant Lymphoproliferative Disease. Am J Transplantation, 5: 566, 2005.

Dotti G, Savoldo B, Pule M, et al Human cytotoxic T-lymphocytes with reduced sensitivity to Fas-induced apoptosis. Blood, 105:4677, 2005.

Lee TC, Savoldo B, Rooney CM, et al. Quantitative EBV Viral Loads and Immunosuppression Alterations can Decrease PTLD Incidence in Pediatric Liver Transplant Recipients. Am J Transplant, 5:2222, 2005.

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(Modified:August 15, 2006- SM)