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Mary Hurwitz, PhD
Education: Research
Interests: Selected
Publications: Chévez-Barrios P., Chintagumpala M., Mieler W., Boniuk M., Paysse E., Kozinetz C., Hurwitz M.Y., Hurwitz R.L. Response of Retinoblastoma with Vitreous Tumor Seeding to Adenovirus-mediated Delivery of Thymidine Kinase Followed by Ganciclovir. J Clin Onc. 23, 7927-7935, 2005. Hurwitz, R.L., Shields, C., Shields, J., Chévez-Barrios, P., Hurwitz, M.Y. and Chintagumpala, M. Retinoblastoma In PA Pizzo and DG Poplack eds. Principles and Practice of Pediatric Oncology (5th edition). Lippincott-Raven, Philadelphia, 2006, pp 861-882.
Department of Pediatrics
Section of Hematology-Oncology,
Baylor College of Medicine
Contact Information:
mhurwitz@bcm.edu
832-824-4257
1980, PhD - University of Minnesota, Minneapolis, MN
Dr. Mary Hurwitz is involved in preclinical and translational
studies to support the use of gene therapy for ocular disorders. Using
both in vitro and in vivo models of retinoblastoma, studies have been
designed to examine viral-mediated gene therapy for the treatment of
tumors in the eye. These studies include 1) elucidation of the unique
properties of adenoviral transduction in the ocular environment, 2)
investigation of the immune consequences of adenoviral-mediated gene
transfer, 3) comparison of suicide gene therapy to gene replacement
therapy, and 4) elucidation of the differences between metastatic and
non-metastatic tumor development. In addition, options for gene replacement
therapy for hereditary retinal degenerative diseases are being examined
using a transgenic mouse model of Stargardt’s disease, a juvenile
macular degenerative disorder caused by a mutation in a protein necessary
for the recycling of the photon receptor retinal.
Plummer, T.H., Jr. and Hurwitz, M.Y.: Human plasma carboxypeptidase
N: Isolation and characterization. J. Biol.
Chem. 253:3907-3912, 1978.
Hurwitz, M.Y. and Edstrom, R.D.: A simple, sensitive radioimmunoassay
for 5'-nucleotidase. Analyt. Biochem. 84:246-250, 1978.
Hurwitz, M.Y., Hurwitz, R.L., and Edstrom, R.D.: Inhibition of human
lymphocyte cyclic nucleotide phosphodiesterases by the chlorinated adenosine
analog DTA-35. J. Enzyme Inhibition 1:267-274, 1987.
Toda, T., Cameron, S., Sass, P., Zoller, M., Scott, J.D., McMullen,
B., Hurwitz, M.Y., Krebs, E.G., and Wiggler, M.: Cloning and characterization
of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent
protein kinase in Saccharomyces cerevisiae. Mol. Cell. Biol. 7:1371-1377,
1987.
Hurwitz, M.Y., Putkey, J.A., Klee, C., and Means, A.R.: Domain II of
calmodulin is involved in activation of calcineurin. FEBS Letters 238:82-86,
1988.
Rossen, R.D., Smith, C.W., Laughter, A.H., Noonan, C.A., Anderson, D.C.,
McShan, W.M., Hurwitz, M.Y., and Orson, F.M.: HIV-1 stimulated expression
of CD11/CD18 integrins and ICAM-1: A possible mechanism for extravascular
dissemination of HIV-1 infected cells. Trans. of the Assoc. Am. Phys.
102:117-130, 1989.
Olson, N.J., Pearson, R.B., Needleman, D., Hurwitz, M.Y., Kemp, B.E.,
and Means, A.R.: Regulatory and structural motifs of chicken gizzard
myosin light chain kinase. Proc. Natl. Acad. Sci. USA 87:2284-2288,
1990.
Hurwitz, R.L., Hirsch, K.M., Clark, D.J., Holcombe, V.N., and Hurwitz,
M.Y.: Induction of a calcium-calmodulin-dependent phosphodiesterase
during PHA-stimulated lymphocyte mitogenesis. J. Biol. Chem. 265:8901-8907,
1990.
Sligh, J.E., Jr., Hurwitz, M.Y., Zhu, C., Anderson, D.C., and Beaudet,
A.L.: An initiation codon mutation in CD18 in association with the moderate
phenotype of leukocyte adhesion deficiency. J. Biol. Chem. 267:714-718,
1992.
Carcamo, B., Hurwitz, M.Y., Craft, C.M., and Hurwitz, R.L.: The pineal
gland expresses the cone but not the rod cGMP phosphodiesterase. J.
Neurochemistry 65:1085-1092, 1995.
Hurwitz, R.L., Srivastava, D., and Hurwitz, M.Y. Channel structure and
divalent cation regulation of phototransduction. Behavioral and Brain
Sciences 18:478, 1995.
Kommonen, B., Kylmä, T., Cohen, R.J., Penn, J.S., Paulin, L., Hurwitz,
M.Y., and Hurwitz, R.L. Elevation of cGMP with normal expression and
activity of rod cGMP-PDE in photoreceptor degenerate labrador retrievers.
Ophthalmic Research 28:19-28, 1996.
Kylma T, Paulin L., Hurwitz M.Y., Hurwitz R.L., Kommonen, B.: Cloning
of the cDNA encoding rod photoreceptor cGMP phosphodiesterase a and
g subunits from the retinal degenerate labrador retriever dog. Res Vet
Sci. 62:293-296, 1997.
Kylma T, Paulin L., Hurwitz M.Y., Hurwitz R.L., Kommonen, B.: Cloning
and analysis of the cDNA encoding the rod G-protein transducin a, b1
and g1 subunits from the canine retina. Gene 193(1):1-4, 1997.
Hurwitz, M.Y., Marcus K.T., Chévez-Barrios P., Louie K., Aguilar-Cordova
C.E., Hurwitz R.L. Suicide gene therapy for treatment of retinoblastoma
in a murine model. Human Gene Therapy 10(3):441-448, 1999.
Chévez-Barrios P., Hurwitz M.Y., Louie K., Marcus K.T., Holcombe
V.N., Schafer P., Aguilar-Cordova E., Hurwitz R.L. Metastatic and non-metastatic
models of retinoblastoma. American Journal of Pathology 157(4):1405-1412,
2000.
Hurwitz R.L., Chévez-Barrios P., Chintagumpala M., Boniuk M.,
Hurwitz M.Y. Gene Therapy for Retinoblastoma. Proceedings of the 4th
Great Basin Visual Science Symposium. 2000 vol 4 http://insight.med.utah.edu/gbs/gbs4/pdf/hurwitz_paper.pdf.
Suber M.L., Hurwitz M.Y., Chévez-Barrios P., Hurwitz R.L. Immune
consequences of intraocular administration of modified adenoviral vectors.
Human Gene Therapy 12: 833-838, 2001.
Hurwitz R.L., Shields C., Shields J., Chévez-Barrios P., Hurwitz,
M.Y., Chintagumpala M. Retinoblastoma, In PA Pizzo and DG Poplack eds.
Principles and Practice of Pediatric Oncology (4th edition). Lippincott-Raven,
Philadelphia, 2002.
Hurwitz, R.L., Chevez-Barrios, P., Boniuk,M., Chintagumpala M., Hurwitz
M.Y. Retinoblastoma: From Bench to Bedside In: Expert Reviews in Molecular
Medicine, Cambridge Press, Cambridge, UK, 2003.
©2002,
Cell And Gene Therapy, Baylor College
of Medicine
One Baylor Plaza, N1002, Houston, TX 77030, (713)798-1246
URL: http://www.bcm.edu/genetherapy
Email:cagt@bcm.edu
(Modified:August 15, 2006- SM)
