Contact Information:
smg@bcm.edu
832-824-4179

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Education:
M.D., Medical School, University of Göttingen, Germany
Research Fellowship in Cell Biology, Baylor College of Medicine, Houston, Texas
Pediatric Residency, Baylor College of Medicine, Houston, Texas
Postdoctoral Fellowship, Pediatric Hematology-Oncology, Texas Children's Cancer Center and Hematology Service, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas

Research Interests:
We are interested in the immunotherapy for virus-associated malignancies and diseases. Immunotherapy with cytotoxic T-cells (CTL) is increasingly used as therapy for malignancies and viral infections. This therapeutic approach has the major advantage of offering specific killing of malignant or viral infected cells with minimal side effects. Our research is focused on a) Epstein-Barr virus associated malignancies such as Hodgkin’s disease and nasopharyngeal carcinoma, and b) HER2-positive malignancies including brain tumors and sarcomas. We are currently conducting Phase I/II clinical studies using antigen-specific CTL and in the laboratory are investigating strategies on how to improve T-cell therapies for cancer.

Selected Publications:
Gottschalk S, Heslop HE, Rooney CM (2005). Adoptive Immunotherapy for EBV-associated Malignancies. Leukemia & Lymphoma 46(1):1-10

Pacheco ES, Gottschalk S, Gresik MV, Dishop MK, Okamura T, McCormick T (2005). Chronic active Epstein Barr Viurs (CAEBV) infection of NK cells presenting as severe skin reaction to mosquito bites. J Allergy Clin Immunol 116(2):470-2.

Bollard CM, Gottschalk S, Huls MH, Molldrem J, Przepoirka D, Rooney CM, Heslop HE (2006). In vivo expansion of LMP1 and 2-specific T cells in a patient who received donor-derived EBV-specific T cells after allogenic stem cell transplantation. Leukemia & Lymphoma 47(5):837-842

Savoldo B, Goss JA, Hammer MM, Zhang L, Lopez T, Gee AP, Lin YF, Quiros-Tejeira RE, Reinke P, Schubert S, Gottschalk S, Finegold MJ, Brenner MK, Rooney CM, Heslop HE (2006). Treatmet of solid organ transplant recipients with autologous Epstein-Barr Virus-specific cytotoxic T lymphocytes (CTL). Blood 108(9):2942-9.

Kennedy-Nasser AA, Leung KS, Mahajan A, Weiss HL, Acre JA, Gottschalk S, Carrum G, Khan SP, Heslop HE, Brenner MK, Bollard CM, Krance RA (2006). Comparable Outcome of matched related and alternative donor stem cell transplantation for pediatric severe aplastic anemia. BBMT 12(12):1277-1284

Leen A, Ratnayake M, Foster A, Heym K, Ahmed N, Rooney CM, Gottschalk S (2007). Contact activated Monocytes: efficient antigen presenting cells for the stimulation of antigen-specific T cells. J Immunother 30:96-107

Seiler MP, Gottschalk S, Cerullo V, Ratnayake M, Mane VP, Clarke C, Ng P, Palmer J, Rooney CM, Lee B (2007). Dendritic Cell function after gene transfer with adenovirus-calcium phosphate co-precipitates. Mol Ther 15(2):386-92

Ahmed A, Ratnayake M, Savoldo B, Perlaky L, Dotti G, Wels WS, Bhattacharjee MB, Gilbertson RJ, Shine HD, Weiss HL, Rooney CM, Heslop HE, Gottschalk S (2007). Regression of experimental medulloblastoma following transfer of HER2-specific T cells. Cancer Res 67(12):5957-64

Louis CU, Paulino AC, Gottschalk S, Bertuch AA, Chintagumpala M, Heslop HE, Russell HV (2007). A single institution experience with pediatric nasopharyngeal carcinoma: High incidence of toxicity associated with platinum-based chemotherapy plus IMRT. J Pediatr Hematol Oncol 29(7):500-505

Bollard CM, Gottschalk S, Khallil M, Gee AP, Mei Z, Weiss H, Gresik MV, Gee AP, Brenner MK, Rooney CM, Heslop HE (2007) Complete Responses of Relapsed Lymphoma Following Genetic Modification of Tumor-Antigen Presenting Cells and T-lymphocyte transfer. Blood 110(8):2838-45