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Gianpietro Dotti, MD
Assistant Professor Education: Selected
Publications: Carlo Stella C, Dotti G, Mangoni L, Regazzi E, Garau D, Bonati A, Almici C, Sammarelli G, Savoldo B, Rizzo MT, Rizzoli V. Selection of myeloid progenitors lacking BCR-ABL mRNA in chronic myelogenous leukemia patients after in vitro treatment with the tyrosine kinase inhibitor genistein. Blood 1996; 88: 3091-3100. Rambaldi A, Borleri G, Dotti G, Bellavia P, Amaru R, Biondi A, Barbui T. Innovative two steps negative selection of G-CSF mobilized circulating progenitor cells: adequacy for autologous and allogeneic transplantation. Blood 91, 1998: 2189-2196. Takahashi S, Rousseasu RF, Yotnda P, Mei Z, Dotti G, Rill D, Hurwitz R, Marini F, Andreeff M, Brenner MK. Autologous antileukemic immune response induced by chronic lymphocytic leukemia B cells expressing the CD40 ligand and Interleukin 2 transgenes. Human Gene Therapy 12: 659-670, 2001. G Dotti, B Savoldo, S Takahashi, T Goltsova, D Rill, C Rooney, M Brenner. Adenovector Induced Expression of Human-CD40-Ligand (hCD40L) By Multiple Myeloma Cells: A Model for Immunotherapy. Experimental Hematology 2001, 29: 952-61. Dotti G, Savoldo B, Yotnda P, Rill D, Brenner MK. Transgenic expression of CD40-ligand (CD40L) produces an in vivo antitumor immune response to both CD40 positive and negative plasmacytoma cells. Blood 2002, 100:200-207. 
Department of Medicine
Center for Cell and Gene Therapy,
Baylor College of Medicine
Contact
Information:
dxgianpe@texaschildrenshospital.org
832-824-4715
M.D., University of Milan, Italy
Fellow, Department of Hematology, University of Parma, Italy
Fellow, Molecular Biology, Department of Hematology, OR Bergamo, Italy
Fellow, Cancer vaccine, Center for Cell and Gene Therapy, Baylor College
of Medicine
Assistant Professor, Department of Hematology, OR Bergamo, Italy
Research Interests:
Dr. Dotti’s current research interest is the development
of immunotherapy strategies for the treatment of B-lymphocyte derived
malignancies.
Barbui A, Galli M, Dotti G, Belli N, Borleri G, Gritti G, Bellavita P, Comotti B, Barbui T, Rambaldi A. Negative selection of peripheral blood stem cells to support a tandem autologous transplantation program in multiple myeloma. British Journal of Haematolology 2002, 116: 202-210.
Yvon ES, Vigouroux S, Rousseau RF, Biagi E, Amrolia P, Dotti G, Wagner HJ, Brenner MK. Over expression of the Notch ligand, Jagged-1 induces alloantigen-specific human regulatory T cells. Blood 2003;102:3815-21.
Savoldo B, Rooney CM, Quiros-Tejera RE, Caldwell Y, Wagner HJ, Lee T, Finegold MJ, Dotti G, Heslop HE, Goss JA. Cellular immunity to Epstein Bar Virus in liver transplant recipients treated with Rituximab for Post-Transplant Lymphoproliferative Disease. Am J Transp 2005;5:566-572.
Biagi E, Dotti G, Yvon E, Lee E, Pule M, Vigouroux S, Gottschalk S, Popat U, Rousseau R, Brenner M.Molecular transfer of CD40 and OX40 ligands to leukemic human B-cells induces expansion of autologous tumor-reactive cytotoxic T-lymphocytes. Blood 2005;105:2346-2442.
Straathof KC, Pulè MA, Yotnda P, Dotti G, Vanin EF, Brenner MK, Heslop HE, Spencer DM, Rooney CM.An inducible Caspase 9 safety switch for cell therapy Blood 2005;105:4247-54.
Dotti G, Savoldo B, Pule M, Straathof KC., Biagi E, Yvon E, Vigouroux S, Brenner MK, Rooney CM. Human Cytotoxic T-Lymphocytes with reduced sensitivity to Fas-induced Apoptosis. Blood 2005;105:4677-84.
Pulè M, Straathof KC, Dotti G, Heslop HE, Rooney CM and Brenner MK. An artificial T cell receptor that induces sustained proliferation and augments cytokine release from primary human T-cells. Molecular Therapy 2005;12:933-41.
Biagi E, Rousseau R, Yvon E, Schwartz M, Dotti G, Foster A, Havlik-Cooper D, Grilley, Gee A, Baker K, Carrum G, Rice L, Andreeff M, Popat U, Brenner M. Responses to human CD40 Ligand/human Interleukin-2 autologous cell vaccine in patients with B-cell chronic lymphocytic leukemia. Clinical Cancer research 2005;11:6916-6923
©2002,
Cell And Gene Therapy, Baylor College
of Medicine
One Baylor Plaza, N1002, Houston, TX 77030, (713)798-1246
URL: http://www.bcm.edu/genetherapy
Email:cagt@bcm.edu
(Modified:August 15, 2006- SM)
