Nabil Ahmed, MD, MSc

Assistant Professor Department of Pediatrics Section of Hematology-Oncology, Baylor College of Medicine

 

Contact Information:
nahmed@bcm.edu
nmahmed@txccc.org
(832)-824-4611

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Education:
BSc in Medical Sciences: Kasr El-Aini School of Medicine, Cairo, Egypt.
MD: Faculty of Medicine, Cairo University, Cairo, Egypt.
Clinical Fellowship in Pediatric Hematology and Oncology: National Cancer Institute, Cairo University, Egypt.
Instructor in Pediatric Hematology and Oncology: National Cancer Institute, Cairo University, Egypt.
Pediatric Residency: Lincoln Hospital, Weill-Cornell Medical College, New York and Children’s Hospital of New Jersey (CHNJ), Mount Sinai School of Medicine. Newark, NJ, U.S.A   
Fellowship in Pediatric Hematology and Oncology: Baylor College of Medicine, Houston, TX, U.S.A  

Board Certifications:
American Board of Pediatrics (ABP): Board Certified in Pediatrics.
Egyptian Ministry of Health and Population.
American Board of Pediatrics (ABP): Board Certified in Pediatric Hematology and Oncology.

Selected Memberships:
Member: American Society of Bone Marrow Transplantation (ASBMT)
Member: American Society of Clinical Oncology (ASCO): member
Member: American Society of Pediatric Hematology and Oncology (ASPHO)
Member: American Society of Hematology (ASH)
Member: Egyptian Medical Syndicate.

Clinical Special Interests:
Bone Marrow Transplantation
Cell and Gene Therapy

Research Interests:
Our laboratory is interested in the adoptive cellular immunotherapy for solid tumors. We have genetically modified T cells to express HER2-specific chimeric antigen receptors (CARs). This therapeutic approach has the major advantage of offering specific killing of malignant cells that express HER2 with minimal side effects.

In a series of preclinical studies done in the laboratories of Drs. Stephen Gottschalk and Helen Heslop, we've shown that HER2-specific T cells from healthy donors and medulloblastoma patients recognize and kill HER2 positive medulloblastoma cell lines as well as autologous primary tumors. In addition, adoptive transfer of HER2-specific T cells induced regression of established medulloblastomas in an orthotopic murine xenograft model. At present we are studying methods to improve the anti-tumor efficacy, growth and survival of genetically modified HER2-specific T cells in the central nervous system and their ability to home to tumor sites to eradicate loco-regionally advanced disease.

In our ongoing work, we are focusing on the development of an innovative immunotherapy approach for pediatric bone sarcomas and breast cancer by targeting HER2.

Selected Publications

Ahmed N, Ratnayake M, Savoldo B, Perlaky L, Dotti G, Wels WS, Bhattacharjee MB, Gilbertson RJ, Shine HD, Weiss HL, Rooney CM, Heslop HE, Gottschalk S (2007). Regression of experimental medulloblastoma following transfer of HER2-specific T cells. Cancer Res (in press)

Ahmed N, Vladislav Chizhevsky (2007). Acute Hepatic Sequestration associated with pneumococcal infection in Sickle β°-Thalassemia. Journal of Pediatric Hematology and Oncology. (in press)

Ahmed N, El-Mahallawy H, Ahmed IA, Nassif S, El-Beshlawy A, El-Haddad A (2007). Early Hospital Discharge versus Continued Hospitalization in Febrile Pediatric Cancer Patients with Prolonged Neutropenia: A Randomized, Prospective Study. Pediatric Blood and Cancer. (in press)

Leen A, Ratnayake M, Foster A, Heym K, Ahmed N, Rooney CM, Gottschalk S. Contact-activated Monocytes: Efficient Antigen Presenting Cells for the Stimulation of Antigen-specific T cells. J Immunother. 2007 Jan;30(1):96-107.

Ahmed N; Heslop HE (2006). “Viral Lymphomagenesis: Pathogenesis of virus-associated malignant lymphomas” Current Opinion in Hematology. Curr Opin Hematol. 2006 Jul;13(4):254-259.

Ahmed, N. Thesis, in partial fulfillment of the Master’s Degree in Pediatric Oncology: “Imipenem/cilastatin Monotherapy vs. Ceftriaxone and Amikacin in the Empiric Treatment of Pediatric Patients with High Risk Fever and Granulocytopenia due to Chemotherapy. Cairo University press. 2000.

 

©2002, Cell And Gene Therapy, Baylor College of Medicine
One Baylor Plaza, N1002, Houston, TX 77030, (713)798-1246
URL: http://www.bcm.edu/genetherapy Email:cagt@bcm.edu
(Modified:August 15, 2006- SM)