Core
B: Cellular and Molecular Morphology Core
Milton
J. Finegold, M.D., Director
Michael Mancini, Ph.D. Co-Director
Christina Thaller, MSc., Associate-Director
The Morphology Core provides expertise, equipment and procedures
relevant to GI research, makes available its specialized laboratory
facilities to GI researchers, and aids the development of
new tests that may be useful in clinical and basic research.
Major core services include histology, immunohistochemistry,
in-situ hybridization, frozen sections for enzyme histochemistry,
immunofluorescent antibody studies, DNA and RNA extraction,
transmission, scanning, and immunoelectron microscopy, quantitative
morphometric analysis and laser capture dissection for molecular
genetic analyses.
The
Core also provides consultation and training in the proper
collection, fixation, storage and handling of human and animal
tissues, as well as training and technical advice to researchers
interested in developing sophisticated procedures for their
GI-related research projects. In coordination with the Study
Design and Clinical Research Core and the Integrative Biology,
a bank of human and mouse gastrointestinal and liver tissue,
both normal and diseased, has been created in order to make
these valuable samples available to center researchers for
specific projects, as controls for their studies, and to test
new reagents and methods. A major benefit of the Core is to
utilize information and expertise gained from diverse projects
in individual laboratories to enhance the productivity of
all DDC researchers.
Please credit the "NIH/National Institute of Diabetes
and Digestive and Kidney Disease, Center Grant P30 DK56338" in
publications resulting from core usage or pilot funds.
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