Cancer stem cells' signature may make them targets
By Ruth SoRelle, M.P.H.
Breast cancer patients who receive anticancer drugs or other therapy may have a subset of tumor cells remaining – a stubborn cluster that is resistant to traditional drugs and may also be able to initiate new tumor growth.
Gene signature
These breast cancer "stem cells" have a specific gene signature, said a consortium of researchers led by Baylor College of Medicine. The report appears in a recent issue of the Proceedings of the National Academy of Sciences.This "signature" could be used as a target against which new drugs can be developed, said Dr. Jenny Chang, medical director of the Sue and Lester Smith Breast Center at BCM and a professor of medicine. Chang is a senior author of the paper along with Drs. Michael Lewis and Jeffrey M. Rosen, both of BCM and the Dan L. Duncan Cancer Center as well as the Breast Center.
"We have found that gene expression patterns in a subset of these resistant cancer cells differ from those associated with the bulk of the epithelial cells in the tumor. These patterns resemble expression patterns more closely associated with cells with a mesenchymal (a form of connective tissue) phenotype (or appearance)," said Chang.
Previous research
In a previous paper, the authors showed that after patients received conventional chemotherapy, the remaining tumor contained a higher percentage of tumor-initiating cells, also known as breast cancer stem cells. These remaining tumor-initiating cells were therefore largely resistant to conventional treatments.
They found that gene expression patterns in these chemoresistant cells represented a tumor-initiating gene signature, which was not only more easily detectable in a newly-defined breast cancer subtype called "claudin-low," but also enriched in human breast tumors after they had been treated with anticancer drugs that target the signals of hormones, said Chang. They also found that genes associated with the mesenchymal cell phenotype were increased in breast tumors after hormone treatment.
Disease recurrence
"This study supports a growing body of evidence that there is a particular subpopulation of cells in breast cancer that may be responsible for disease recurrence, resistance to treatment and perhaps metastasis (cancer spread)," said Chang.
In the future, she said, the group will be looking at ways to use the gene signature they have identified to develop drugs that can combine with conventional therapy to eradicate all populations of cells within tumors.
Others who took part in this research include Chad J. Creighton, Xiaoxian Li, Melissa Landis, Helen Wong, Angel Rodriguez, Jason I. Herschkowitz, Xiamoei Zhang, Anne Pavlick, M. Carolina Gutierrez, and Susan G. Hilsenbeck, all of the Dan L. Duncan Cancer Center at BCM; J. Michael Dixon, Lorna Renshaw, Alexey A. Larionov and Dana Faratian of Western General Hospital in Edinburgh, UK;Veronique M. Neumeister, Ashley Sjohund, David L. Rimm and Xiaping He, all of Yale University School of Medicine in New Haven, CT; Cheng Fan and Charles M. Perou, both of Unversity of North Carolina at Chapel Hill.
Funding for this study came from the Breast Cancer Research Fundation, the Helis Foundation, the National Cancer Institute Breast Cancer Special Program of Research Excellence, the National Cancer Institute, the Breakthrough Research Unit in Edinburgh, Cancer Research UK, the National Institutes of Health, Glaxo Smith Kline and the U.S. Army Medical Research and Materiel Command.
Rosen is the C.C. Bell Professor in the department of molecular and cellular biology.
Chang holds a Dan L. Duncan Professorship.
