Vaccines help kick drug habits
By Graciela Gutierrez
Addicts trying to kick their drug habit could find help through the use of two new vaccines.
The vaccines designed to combat cocaine and methamphetamine dependencies not only relieve addiction but also minimize withdrawal symptoms, according to results of a study by Baylor College of Medicine researchers.
Antibodies attack drug in bloodstream
The vaccines stimulate the body to produce antibodies which then attack the drug while it is in the blood stream. This prevents the drug from reaching the brain and creating the reactions that contribute to dependency.
"These are therapeutic, not preventative, vaccines," said lead investigator Thomas Kosten, M.D., the Jay H. Waggoner professor of psychiatry and behavioral sciences at the Menninger Department of Psychiatry at BCM and research director of the Veteran Affairs National Substance Use Disorders Quality Enhancement Research Initiative. "They are meant for those who are already suffering from drug addiction."
Not stand-alone treatment
Kosten stresses that while the vaccines have been shown to help overcome drug addictions, they do not necessarily curb relapse.
"This is not a stand-alone treatment," Kosten said. "There is a reason drugs were used in the first place, and that needs to be dealt with either through counseling or behavioral therapies."
No withdrawal
TA-CD, the cocaine vaccine, works through a series of injections over a three-month period. Study participants began to respond favorably to the vaccine after about a month. TA-CD has one more large scale human study scheduled before it is ready for the FDA approval process.
"The vaccine slowly decreases the amount of cocaine that reaches the brain," Kosten said. "It's a slow process, and patients do not go through any significant withdrawal symptoms."
Antibody production was sustained for another nine months following the vaccine treatment. Additional injections were subsequently administered every four to eight weeks, if needed at all.
The methamphetamine vaccine, still in early stages of development, has produced similar results as TA-CD. While both vaccines spur antibody production, each has a unique protein composition that help the body target the different drugs.
Both studies are being funded by the National Institute on Drug Abuse, part of the National Institutes of Health.
