The Students

Current Students

Current Students’ Publications

Pappu KS, Ostrin EJ, Middlebrooks BW, Silo BT, Chen R, Atkins MR, Gibbs R, Mardon G (2005) Dual regulation and redundant function of two eye-specific enhancers of the Drosophila retinal determination gene dachshund. Development 132:2895-2905.

Pepple KL, Atkins M, Venken K, Wellnitz K, Harding M, Frankfort B, Mardon G (2008) Two-step selection of a single R8 photoreceptor: a bistable loop between senseless and rough locks in R8 fate. Development 135:4071-4079.

Berry J, Krause WC, Davis RL (2008) Olfactory memory traces in Drosophila. Progress in Brain Research 169:293-304.

Koster MI, Dai D, Roop DR (2007) Conflicting roles for p63 in skin development and carcinogenesis. Cell Cycle 6:269-273.

Koster MI, Dai D, Marinari B, Sano Y, Costanzo A, Karin M, Roop DR (2007) p63 induces key target genes required for epidermal morphogenesis. Proceedings of the National Academy of Sciences USA 104:3255-3260.

Plas DT, Dhande OS, Lopez JE, Murali D, Thaller C, Henkemeyer M, Furuta Y, Overbeek P, Crair MC (2008) Bone morphogenetic proteins, eye patterning, and retinocollicular map formation in the mouse. Journal of Neuroscience 28:7057-7067.

Griswold SL, Behringer RR (2009) Fetal Leydig cell origin and development. Sexual Development 3:1-15.

Hamaratoglu F, Willecke M, Kango-Singh M, Nolo R, Hyun E, Tao C, Jafar-Nejad H, Halder G (2006) The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nature Cell Biology 8:27-36.

Lam YC, Bowman AB, Jafar-Nejad P, Lim J, Richman R, Fryer JD, Hyun ED, Duvick LA, Orr HT, Botas J, Zoghbi HY (2006) ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology. Cell 127:1335-1347.

Nam SC, Mukhopadhyay B, Choi KW (2007) Antagonistic functions of Par-1 kinase and protein phosphatase 2A are required for localization of Bazooka and photoreceptor morphogenesis in Drosophila. Developmental Biology 306:624-635.

Choi KW, Nam SC, Mukhopadhyay B (2007) Par-1 and PP2A: Yin-Yang of Bazooka localization. Fly 1:235-237.

Ginger MR, Shore AN, Contreras A, Rijnkels M, Miller J, Gonzalez-Rimbau MF, Rosen JM (2006) A noncoding RNA is a potential marker of cell fate during mammary gland development. Proceedings of the National Academy of Sciences U.S.A. 103:5781-5786.

Xu D, Woodfield SE, Lee TV, Fan Y, Antonio C, Bergmann A (2009) Genetic control of programmed cell death (apoptosis) in Drosophila. Fly 3:78-90.

Herz HM, Woodfield SE, Chen Z, Bolduc C, Bergmann A (2009) Common and distinct genetic properties of ESCRT-II components in Drosophila. PLoS ONE 4:e4165.

Andrews HK, Giagtzoglou N, Yamamoto S, Schulze KL, Bellen HJ (2009) Sequoia regulates cell fate decisions in the external sensory organs of adult Drosophila. EMBO Reports 10:636-664.

Past Students

Past Students’ Publications

Albrecht U, Abu-Issa R, Ratz B, Hattori M, Aoki J, Arai H, Inoue K, Eichele G (1996) Platelet-activating factor acetylhydrolase expression and activity suggest a link between neuronal migration and platelet-activating factor. Developmental Biology 180:579-593.

Abu-Issa R, Eichele G, Youssoufian H (2000) Expression of the Fanconi anemia group A gene (Fanca) during mouse embryogenesis. Blood 94:818-824.

Jafar-Nejad H*, Acar M*, Nolo R, Lacin H, Pan H, Parkhurst SM, Bellen HJ (2003) Senseless acts as a binary switch during sensory organ precursor selection. Genes and Development 17:2966-2978. (*The first two authors contributed equally to this work.)

Jafar-Nejad H, Andrews HK, Acar M, Bayat V, Wirtz-Peitz F, Mehta SQ, Knoblich JA, Bellen HJ (2005) Sec15, a component of the exocyst, promotes Notch signaling during the asymmetric division of Drosophila sensory organ precursors. Developmental Cell 9:351-363.

Jafar-Nejad H, Tien AC, Acar M, Bellen HJ (2006) Senseless and Daughterless confer neuronal identity to epithelial cells in the Drosophila wing margin. Development 133:1683-1692.

Acar M, Jafar-Nejad H, Giagtzoglou N, Yallampalli S, David G, He Y, Delidakis C, Bellen HJ (2006) Senseless physically interacts with proneural proteins and functions as a transcriptional co-activator. Development 133:1979-1989.

Jafar-Nejad H, Andrews HK, Acar M, Bayat V, Wirtz-Peitz F, Mehta SQ, Knoblich JA, Bellen HJ (2005) Sec15, a component of the exocyst, promotes Notch signaling during the asymmetric division of Drosophila sensory organ precursors. Developmental Cell 9:351-363.

Park Y, Mengus G, Bai X, Kageyama Y, Meller VH, Becker PB, Kuroda MI (2003) Sequence-specific targeting of Drosophila roX genes by the MSL dosage compensation complex. Molecular Cell 11:977-986.

Bai X, Alekseyenko AA, Kuroda MI (2004) Sequence-specific targeting of MSL complex regulates transcription of the roX RNA genes. EMBO Journal 23:2853-2861.

Oh H, Bai X, Park Y, Bone JR, Kuroda MI (2005) Targeting dosage compensation to the X chromosome of Drosophila males. Cold Spring Harbor Symposia on Quantitative Biology 69:1-8.

Bailey TJ, El-Hodiri H, Zhang L, Shah R, Mathers PH, Jamrich M (2004) Regulation of vertebrate eye development by Rx genes. International Journal of Developmental Biology 48:761-770.

Chang H, Huylebroeck D, Verschueren K, Guo Q, Matzuk MM, Zwijsen A (1999) Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects. Development 126:1631-1642.

Chang H, Zwijsen A, Vogel H, Huylebroeck D, Matzuk MM (2000) Smad5 is essential for left-right asymmetry in mice. Developmental Biology 219:71-78.

Chang H, Matzuk MM (2001) Smad5 is required for mouse primordial germ cell development. Mechanisms of Development 104:61-67.

Chang H, Lau AL, Matzuk MM (2001) Studying TGF-β superfamily signaling by knockouts and knockins. Molecular and Cellular Endocrinology 180:39-46.

Chang H, Brown CW, Matzuk MM (2002) Genetic analysis of the mammalian transforming growth factor-β superfamily. Endocrine Reviews 23:787-823.

Chen R, Amoui M, Zhang Z, Mardon G (1997) Dachshund and eyes absent proteins form a complex and function synergistically to induce ectopic eye development in Drosophila. Cell 91:893-903.

Chen R, Halder G, Zhang Z, Mardon G (1999) Signaling by the TGF-β homolog decapentaplegic functions reiteratively within the network of genes controlling retinal cell fate determination in Drosophila. Development 126:935-943.

Pappu KS, Chen R, Middlebrooks BW, Woo C, Heberlein U, Mardon G (2003) Mechanism of hedgehog signaling during Drosophila eye development. Development 130:3053-3062.

Chen YT, Bradley A (2000) A new positive/negative selectable marker, puΔtk, for use in embryonic stem cells. Genesis 28:31-35.

Chen YT, Liu P, Bradley A (2004) Inducible gene trapping with drug-selectable markers and Cre/loxP to identify developmentally regulated genes. Molecular and Cellular Biology 24:9930-9941.

Chen YT, Levasseur R, Vaishnav S, Karsenty G, Bradley A (2004) Bigenic Cre/loxP, puΔtk conditional genetic ablation. Nucleic Acids Research 32:e161.

Eakin GS, Behringer RR (2003) Tetraploid development in the mouse. Developmental Dynamics 228:751-766.

Eakin GS, Behringer RR (2004) Gastrulation in other mammals and humans. In Gastrulation: from cells to embryos, ed. Stern C. Cold Spring Harbor Press, NY, pp. 275-287.

Eakin GS, Behringer RR (2004) Diversity of germ layer and axis formation among mammals. Seminars in Cell and Developmental Biology 15:619-629.

Eakin GS, Hadjantonakis AK, Papaioannou VE, Behringer RR (2005) Developmental potential and behavior of tetraploid cells in the mouse embryo. Developmental Biology 288:150-159.

Hamaratoglu F, Willecke M, Kango-Singh M, Nolo R, Hyun E, Tao C, Jafar-Nejad H, Halder G (2006) The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nature Cell Biology 8:27-36.

Willecke M, Hamaratoglu F, Kango-Singh M, Udan R, Chen CL, Tao C, Zhang X, Halder G (2006) The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size. Current Biology 16:2090-2100.

Hsu YC, Chern JJ, Cai Y, Liu M, Choi KW (2007) Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase. Nature 445:785-788.

Lim J, Lee OK, Hsu YC, Singh A, Choi KW (2007) Drosophila TRAP230/240 are essential coactivators for Atonal in retinal neurogenesis. Developmental Biology 308:322-330.

Inan M, Lu HC, Albright MJ, She WC, Crair MC (2006) Barrel map development relies on protein kinase A regulatory subunit II β-mediated cAMP signaling. Journal of Neuroscience 26:4338-4349.

Inan M, Crair MC (2007) Development of cortical maps: perspectives from the barrel cortex. The Neuroscientist 13:49-61.

Albright MJ, Weston MC, Inan M, Rosenmund C, Crair MC (2007) Increased thalamocortical synaptic response and decreased layer IV innervation in GAP-43 knockout mice. Journal of Neurophysiology 98:1610-1625.

Iwasato T*, Inan M*, Kanki H, Erzurumlu RS, Itohara S, Crair MC (2008) Cortical adenylyl cyclase 1 is required for thalamocortical synapse maturation and proper layer IV neuronal morphology during barrel map development. In press. (*The first two authors contributed equally to this work.)

Jorgez CJ, Klysik M, Jamin SP, Behringer RR, Matzuk MM (2004) Granulosa cell-specific inactivation of follistatin causes female fertility defects. Molecular Endocrinology 18:953-967.

Pangas SA, Jorgez CJ, Matzuk MM (2004) Growth differentiation factor 9 regulates expression of the bone morphogenetic protein antagonist gremlin. Journal of Biological Chemistry 279:32281-32286.

Yao HH, Matzuk MM, Jorgez CJ, Menke DB, Page DC, Swain A, Capel B (2004) Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis. Developmental Dynamics 230:210-215.

Wang XP, Suomalainen M, Jorgez CJ, Matzuk MM, Wankell M, Werner S, Thesleff I (2004) Modulation of activin/bone morphogenetic protein signaling by follistatin is required for the morphogenesis of mouse molar teeth. Developmental Dynamics 231:98-108.

Wang XP, Suomalainen M, Jorgez CJ, Matzuk MM, Werner S, Thesleff I (2004) Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation. Developmental Cell 7:719-730.

Jorgez CJ, Lin YN, Matzuk MM (2005) Genetic manipulations to study reproduction. Molecular and Cellular Endocrinology 234:127-135.

Kibler K, Svetz J, Nguyen TL, Shaw C, Shaulsky G (2003) A cell-adhesion pathway regulates intercellular communication during Dictyostelium development. Developmental Biology 264:506-521.

Kibler K, Nguyen TL, Svetz J, Van Driessche N, Ibarra M, thompson C, Shaw C, Shaulsky G (2003) A novel developmental mechanism in Dictyostelium revealed in a screen for communication mutants. Developmental Biology 259:193-208.

Tsang TE, Shawlot W, Kinder SJ, Kobayashi A, Kwan KM, Schughart K, Kania A, Jessell TM, Behringer RR, Tam PP (2000) Lim1 activity is required for intermediate mesoderm differentiation in the mouse embryo. Developmental Biology 223:77-90.

Kobayashi A, Behringer RR (2003) Developmental genetics of the female reproductive tract in mammals. Nature Reviews Genetics 4:969-980.

Kobayashi A, Shawlot W, Kania A, Behringer RR (2004) Requirement of Lim1 for female reproductive tract development. Development 131:539-549.

Chaboissier MC, Kobayashi A, Vidal VI, Lutzkendorf S, van de Kant HJ, Wegner M, de Rooij DG, Behringer RR, Schedl A (2004) Functional analysis of Sox8 and Sox9 during sex determination in the mouse. Development 131:1891-1901.

Kobayashi A, Kwan KM, Carroll TJ, McMahon AP, Mendelsohn CL, Behringer RR (2005) Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development. Development 132:2809-2823.

Kobayashi A, Chang H, Chaboissier MC, Schedl A, Behringer RR (2005) Sox9 in testis determination. Annals of the New York Academy of Sciences 1061:9-17.

Koh T-W, Bellen HJ (2003) Synaptotagmin I, a Ca²⁺ sensor for neurotransmitter release. Trends in Neuroscience 26:413-422.

Zhai RG, Hiesinger PR, Koh T-W, Verstreken P, Schulze KL, Cao Y, Jafar-Nejad H, Norga KK, Pan H, Bayat V, Greenbaum MP, Bellen HJ (2003) Mapping Drosophila mutations with molecularly defined P element insertions. Proceedings of the National Academy of Sciences U.S.A. 100:10860-10865.

Verstreken P*, Koh T-W*, Schulze KL, Zhai RG, Hiesinger PR, Zhou Y, Mehta SQ, Cao Y, Roos J, Bellen HJ (2003) Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoating. Neuron 40:733-748. (*The first two authors contributed equally to this work.)

Koh T-W*, Verstreken P*, Bellen HJ (2004) The Drosophila Dap160 protein is required for endocytosis and acts as a multifunctional temperature sensitive adaptor for numerous endocytic proteins. Neuron 43:193-205. (*The first two authors contributed equally to this work.)

Liefer KM, Koster MI, Wang XJ, Yang A, McKeon F, Roop DR (2000) Down-regulation of p63 is required for epidermal UV-B-induced apoptosis. Cancer Research 60:4016-4020.

Koster MI, Huntzinger KA, Roop DR (2002) Epidermal differentiation: transgenic/knockout mouse models reveal genes involved in stem cell fate decisions and commitment to differentiation. Journal of Investigative Dermatology Symposium Proceedings 7:41-45.

Li AG, Koster MI, Wang XJ (2003) Roles of TGFβ signaling in epidermal/appendage development. Cytokine and Growth Factor Reviews 14:99-111.

Koster MI, Kim S, Mills AA, DeMayo FJ, Roop DR (2004) p63 is the molecular switch for initiation of an epithelial stratification program. Genes and Development 18:126-131.

Koster MI, Roop DR (2004) The role of p63 in development and differentiation of the epidermis. Journal of Dermatological Science 34:3-9.

Koster MI, Roop DR (2004) Transgenic mouse models provide new insights into the role of p63 in epidermal development. Cell Cycle. 3:411-413.

Honeycutt KA, Koster MI, Roop DR (2004) Genes involved in stem cell fate decisions and commitment to differentiation play a role in skin disease. Journal of Investigative Dermatology Symposium Proceedings 9:261-268.

Koster MI, Roop DR (2004) p63 and epithelial appendage development. Differentiation 72:364-370.

Koster MI, Roop DR (2004) Genetic pathways required for epidermal morphogenesis. European Journal of Cell Biology 83:625-629.

Koster MI, Roop DR (2005) Asymmetric cell division in skin development: a new look at an old observation. Developmental Cell 9:444-446.

Koster MI, Kim S, Roop DR (2005) P63 deficiency: a failure of lineage commitment or stem cell maintenance? Journal of Investigative Dermatology Symposium Proceedings 10:118-123.

Matzuk MM, Kumar TR, Shou W, Coerver KA, Lau AL, Behringer RR, Finegold MJ (1996) Transgenic models to study the roles of inhibins and activins in reproduction, oncogenesis, and development. Recent Progress in Hormone Research 51:123-157.

Lau AL, Nishimori K, Matzuk MM (1996) Structural analysis of the mouse activin βC gene. Biochimica et Biophysica Acta 1307:145-148.

Ferguson CA, Tucker AS, Christensen L, Lau AL, Matzuk MM, Sharpe PT (1998) Activin is an essential early mesenchymal signal in tooth development that is required for patterning of the murine dentition. Genes and Development 12:2636-2649.

Lau AL, Kumar TR, Nishimori K, Bonadio J, Matzuk MM (2000) Activin βC and βE genes are not essential for mouse liver growth, differentiation, and regeneration. Molecular and Cellular Biology 20: 6127-6137.

Chang H, Lau AL, Matzuk MM (2001) Studying TGF-β superfamily signaling by knockouts and knockins. Molecular and Cellular Endocrinology 180:39-46.

Yan C, Pendola FL, Jacob R, Lau AL, Eppig JJ, Matzuk MM (2001) Oosp1 encodes a novel mouse oocyte-secreted protein. Genesis 31:105-110.

Ramirez-Solis R*, Liu P*, Bradley A (1995) Chromosome engineering in mice. Nature 378:720-724. (*The first two authors contributed equally to this work.)

Bradley A, Liu P (1996) Target practice in transgenics. Nature Genetics 14:121-123.

Bradley A, Zheng B, Liu P (1998) Thirteen years of manipulating the mouse genome: a personal history. International Journal of Developmental Biology 42:943-950.

Liu P, Zhang H, McLellen A, Vogel H, Bradley A (1998) Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11. Genetics 150:1155-1168.

Liu P, Wakamiya M, Shea MJ, Albrecht U, Berhringer RR, Bradley A (1999) Requirement for Wnt3 in vertebrate axis formation. Nature Genetics 22:361-365.

Fernández-Fúnez P*, Lu C-H*, Rincón-Limas DE, García-Bellido A, Botas J (1998) The relative expression amounts of apterous and its co-factor dLdb/Chip are critical for dorso-ventral compartmentalization in the Drosophila wing. EMBO Journal 17:6846-6853. (*The first two authors contributed equally to this work.)

Rincón-Limas DE*, Lu C-H*, Canal I, Calleja M, Rodríguez-Esteban C, Izpisúa-Belmonte JC, Botas J (1999) Conservation of the expression and function of apterous orthologs in Drosophila and mammals. Proceedings of the National Academy of Sciences USA 96:2165-2170. (*The first two authors contributed equally to this work.)

Rincón-Limas DE, Lu C-H, Canal I, Botas J (2000) The level of DLDB/CHIP controls the activity of the LIM homeodomain protein Apterous: evidence for a functional tetramer complex in vivo. EMBO Journal 19:2602-2614.

Lu C-H, Rincón-Limas DE, Botas J (2000) Conserved overlapping and reciprocal expression of msh/Msx1 and apterous/Lhx2 in Drosophila and mice. Mechanisms of Development 99:177-181.

Lutz B*, Lu HC*, Eichele G, Miller D, Kaufman TC (1996) Rescue of Drosophila labial null mutant by the chicken ortholog Hoxb-1 demonstrates that the function of Hox genes is phylogenetically conserved. Genes and Development 10:176-184. (*The first two authors contributed equally to this work.)

Lu H-C, Eichele G, Thaller C (1997) Ligand-bound RXR can mediate retinoid signal transduction during embryogenesis. Development 124:195-203.

Lu H-C, Revelli J-P, Goering L, Thaller C, Eichele G (1997) Retinoid signaling is required for the establishment of a ZPA and for the expression of Hoxb-8, a mediator of ZPA formation. Development 124:1643-1651.

Lu H-C, Swindell EC, Sierralta WD, Eichele G, Thaller C (2001) Evidence for a role of protein kinase C in FGF signal transduction in the developing chick limb bud. Development 128:2451-2460.

Zhou Z, Mangahas PM, Yu X (2004) The genetics of hiding the corpse: engulfment and degradation of apoptotic cells in C. elegans and D. melanogaster. Current Topics in Developmental Biology 63:91-143.

Mangahas PM, Zhou Z (2005) Clearance of apoptotic cells in Caenorhabditis elegans. Seminars in Cell and Developmental Biology 16:295-306.

Mangahas PM, Yu X, Miller KG, Zhou Z (2008) The small GTPase Rab2 functions in the removal of apoptotic cells in Caenorhabditis elegans. Journal of Cell Biology 180:357-373.

Tavsanli BC, Pappu KS, Mehta SQ, Mardon G (2001) dbest1, a Drosophila homolog of human Bestrophin, is not required for viability or photoreceptor integrity. Genesis 31:130-136.

Verstreken P, Koh TW, Schulze KL, Zhai RG, Hiesinger PR, Zhou Y, Mehta SQ, Cao Y, Roos J, Bellen HJ (2003) Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoating. Neuron 40:733-48.

Mehta SQ, Hiesinger PR, Beronja S, Zhai RG, Schulze KL, Verstreken P, Cao Y, Zhou Y, Tepass U, Crair MC, Bellen HJ (2005) Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components. Neuron 46:219-232.

Hiesinger PR, Fayyazuddin A, Mehta SQ, Rosenmund T, Schulze KL, Zhai RG, Verstreken P, Cao Y, Zhou Y, Kunz J, Bellen HJ (2005) The v-ATPase V₀ subunit a1 is required for a late step in synaptic vesicle exocytosis in Drosophila. Cell 121:607-620.

Jafar-Nejad H, Andrews HK, Acar M, Bayat V, Wirtz-Peitz F, Mehta SQ, Knoblich JA, Bellen HJ (2005) Sec15, a component of the exocyst, promotes Notch signaling during the asymmetric division of Drosophila sensory organ precursors. Developmental Cell 9:351-363.

Wu S, Mehta SQ, Pichaud F, Bellen HJ, Quiocho FA (2005) Sec15 interacts with Rab11 via a novel domain and affects Rab11 localization in vivo. Nature Structural and Molecular Biology 12:879-885.

Nolo R, Morrison CM, Tao C, Zhang X, Halder G (2006) The bantam microRNA is a target of the hippo tumor-suppressor pathway. Current Biology 16:1895-1904.

Papa R, Morrison CM, Walters JR, Counterman BA, Chen R, Halder G, Ferguson L, Chamberlain N, Ffrench-Constant R, Kapan DD, Jiggins CD, Reed RD, McMillan WO (2008) Highly conserved gene order and numerous novel repetitive elements in genomic regions linked to wing pattern variation in Heliconius butterflies. BMC Genomics 9:345.

Cinar HN, Richards KL, Oommen KS, Newman AP (2003) The EGL-13 SOX domain transcription factor affects the uterine π cell lineages in Caenorhabditis elegans. Genetics 165:1623-1628.

Oommen KS, Newman AP (2007) Co-regulation by Notch and Fos is required for cell fate specification of intermediate precursors during C. elegans uterine development. Development 134:3999-4009.

Tavsanli BC, Pappu KS, Mehta SQ, Mardon G (2001) dbest1, a Drosophila homolog of human Bestrophin, is not required for viability or photoreceptor integrity. Genesis 31:130-136.

Pappu KS, Mardon G (2002) Retinal specification and determination in Drosophila. In Results and problems in cell differentiation, ed: K. Moses. Springer-Verlag, Berlin Heidelberg, pp. 5-20.

Pappu KS, Chen R, Middlebrooks BW, Woo C, Heberlein U, Mardon G (2003) Mechanism of hedgehog signaling during Drosophila eye development. Development 130:3053-3062.

Pappu KS, Mardon G (2004) Genetic control of retinal specification and determination in Drosophila. International Journal of Developmental Biology 48:913-24.

Pappu KS, Ostrin EJ, Middlebrooks BW, Sili BT, Chen R, Atkins MR, Gibbs R, Mardon G (2005) Dual regulation and redundant function of two eye-specific enhancers of the Drosophila retinal determination gene dachshund. Development 132:2895-2905.

Norga KK, Gurganus MC, Dilda CL, Yamamoto A, Lyman RF, Patel PH, Rubin GM, Hoskins RA, Mackay TF, Bellen HJ (2003) Quantitative analysis of bristle number in Drosophila mutants identifies genes involved in neural development. Current Biology 13:1388-1396.

Poché RA, Kwan KM, Raven MA, Furuta Y, Reese BE, Behringer RR (2007) Lim1 is essential for the correct laminar positioning of retinal horizontal cells. Journal of Neuroscience 27:14099-14107.

Salzberg A, Prokopenko SN, He Y, Tsai P, Pal M, Maroy P, Glover DM, Deak P, Bellen HJ (1997) P-element insertion alleles of essential genes on the third chromosome of Drosophila melanogaster: mutations affecting embryonic PNS development. Genetics 147:1723-1741.

Hassan BA, Prokopenko SN, Breuer S, Zhang B, Paululat A, Bellen HJ (1998) skittles, a Drosophila phosphatidylinositol 4-phosphate 5-kinase, is required for cell viability, germline development and bristle morphology, but not for neurotransmitter release. Genetics 150:1527-1537.

Prokopenko SN, Brumby A, O’Keefe L, Prior L, He Y, Saint R, Bellen HJ (1999) A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in Drosophila. Genes and Development 13:2301-2314.

Prokopenko SN, Saint R, Bellen HJ (2000) Tissue distribution of PEBBLE RNA and Pebble protein during Drosophila embryonic development. Mechanisms of Development 90:269-273.

Prokopenko SN, Saint R, Bellen HJ (2000) Untying the Gordian knot of cytokinesis: role of small G proteins and their regulators. Journal of Cell Biology 148:843-848.

Prokopenko SN, He Y, Lu Y, Bellen HJ (2000) Mutations affecting the development of the peripheral nervous system in Drosophila: a molecular screen for novel proteins. Genetics 156:1691-1715.

Steffensen S, Coelho PA, Cobbe N, Vass S, Costa M, Hassan B, Prokopenko SN, Bellen HJ, Heck MM, Sunkel CE (2001) A role for Drosophila SMC4 in the resolution of sister chromatids in mitosis. Current Biology 11:295-307.

Beckstead R, Ortiz JA, Sanchez C, Prokopenko SN, Chambon P, Losson R, Bellen HJ (2001) Bonus, a Drosophila homolog of TIF1 proteins, interacts with nuclear receptors and can inhibit βFTZ-F1-dependent transcription. Molecular Cell 7:753-765.

Frankfort BJ, Pepple KL, Mamlouk M, Rose MF, Mardon G (2004) Senseless is required for pupal retinal development in Drosophila. Genesis 38:182-194.

Tsuda H, Jafar-Nejad H, Patel AJ, Sun Y, Chen HK, Rose MF, Venken KJT, Botas J, Orr HT, Bellen HJ, Zoghbi HY (2005) The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins. Cell 122:633-644.

Wang VY*, Rose MF*, Zoghbi HY (2005) Math1 expression redefines the rhombic lip and reveals novel lineages within the brainstem and cerebellum. Neuron 48:31-43. (*The first two authors contributed equally to this work.)

Young JI, Hong EP, Castle JC, Crespo-Barreto J, Bowman AB, Rose MF, Kang D, Richman R, Johnson JM, Berget S, Zoghbi HY (2005) Regulation of RNA splicing by the methylation-dependent transcriptional repressor MeCP2. Proceedings of the National Academy of Sciences U.S.A. 106:17551-17558.

Chizhikov VV, Lindgren AG, Currle DS, Rose MF, Monuki ES, Millen KJ (2006) The roof plate regulates cerebellar cell-type specification and proliferation. Development 133:2793-2804.

Englund C, Kowalczyk T, Daza RA, Dagan A, Lau C, Rose MF, Hevner RF (2006) Unipolar brush cells of the cerebellum are produced in the rhombic lip and migrate through developing white matter. Journal of Neuroscience 26:9184-9195.

Seto ES, Bellen HJ, Lloyd TE (2002) When cell biology meets development: endocytic regulation of signaling pathways. Genes and Development 16:1314-1336.

Seto ES, Bellen HJ (2004) The ins and outs of Wingless signaling. Trends in Cell Biology 14:45-53.

Seto ES, Bellen HJ (2006) Internalization is required for proper Wingless signaling in Drosophila melanogaster. Journal of Cell Biology 173:95-106.

Fernández-Fúnez P, Niño-Rosales ML, de Gouyon B, She W-C, Luchack JM, Martinez P, Turiegano E, Benito J, Capovilla M, Skinner PJ, McCall A, Canal I, Orr HT, Zoghbi HY, Botas J (2000) Identification of genes that modify ataxin-1-induced neurodegeneration. Nature 408:101-106.

Su H, Wang X, Bradley A (2000) Nested chromosomal deletions induced with retroviral vectors in mice. Nature Genetics 24:92-95.

Pershouse M, Li J, Yang C, Su H, Brundage E, Di W, Biggs PJ, Bradley A, Chinault AC (2000) BAC contig from a 3-cM region of mouse chromosome 11 surrounding Brca1. Genomics 69:139-142.

Lindsay EA, Vitelli F, Su H, Morishima M, Huynh T, Pramparo T, Jurecic V, Ogunrinu G, Sutherland HF, Scambler PJ, Bradley A, Baldini A (2001) Tbx1 haploinsufficieny in the DiGeorge syndrome region causes aortic arch defects in mice. Nature 410:97-101.

Su H, Mills AA, Wang X,Bradley A (2001) A targeted X-linked CMV-Cre line. Genesis 32:187-188.

Wang X, Su H, Bradley A (2002) Molecular mechanisms governing Pcdh-γ gene expression: evidence for a multiple promoter and cis-alternative splicing model. Genes and Development 216:1890-1905.

Wang X, Su H, Copenhagen LD, Vaishnav S, Pieri F, Shope CD, Brownell WE, De Biasi M, Paylor R, Bradley A (2002) Urocortin-deficient mice display normal stress-induced anxiety behavior and autonomic control but an impaired acoustic startle response. Molecular and Cellular Biology 22:6605-6610.

Sands A, Suraokar M, Sanchez A, Donehower L, Bradley A (1995) p53 deficiency does not affect the accumulation of point mutations in a transgene target. Proceedings of the National Academy of Sciences U.S.A. 2:8517-8521.

Suraokar M, Bradley A (2000) Genetics. Targeting sheep. Nature 405:1004-1005.

Zheng B, Sage M, Cai WW, Thompson DM, Tavsanli BC, Cheah YC, Bradley A (1999) Engineering a mouse balancer chromosome. Nature Genetics 22:375-378.

Tavsanli BC, Pappu KS, Mehta SQ, Mardon G (2001) dbest1, a Drosophila homolog of human Bestrophin, is not required for viability or photoreceptor integrity. Genesis 31:130-136.

Davis RJ, Tavsanli BC, Dittrich C, Walldorf U, Mardon G (2003) Drosophila retinal homeobox (drx) is not required for establishment of the visual system, but is required for brain and clypeus development. Developmental Biology 259:272-287.

Tavsanli BC, Ostrin EJ, Burgess HK, Middlebrooks BW, Pham TA, Mardon G (2004) Structure-function analysis of the Drosophila retinal determination protein Dachshund. Developmental Biology 272:231-247.

Welm BE*, Tepera SB*, Venezia T, Graubert TA, Rosen JM, Goodell MA (2002) Sca-1^pos cells in the mouse mammary gland represent an enriched progenitor cell population. Developmental Biology 245:42-56. (*The first two authors contributed equally to this work.)

Tepera SB, McCrea PD, Rosen JM A β-catenin survival signal is required for normal lobular development in the mammary gland. (2003) Journal of Cell Science 116: 1137-1149.

Jafar-Nejad H, Tien AC, Acar M, Bellen HJ (2006) Senseless and Daughterless confer neuronal identity to epithelial cells in the Drosophila wing margin. Development 133:1683-1692.

Ohyama T, Verstreken P, Ly CV, Rosenmund T, Rajan A, Tien AC, Haueter C, Schulze KL, Bellen HJ (2007) Huntingtin-interacting protein 14, a palmitoyl transferase required for exocytosis and targeting of CSP to synaptic vesicles. Journal of Cell Biology 179:1481-1496.

Tien AC*, Rajan A*, Schulze KL, Ryoo HD, Acar M, Steller H, Bellen HJ (2008) Ero1L, a thiol oxidase, is required for Notch signaling through cysteine bridge formation of the Lin12-Notch repeats in Drosophila melanogaster. Journal of Cell Biology 182:1113-1125. (*The first two authors contributed equally to this work.)

Udan RS, Kango-Singh M, Nolo R, Tao C, Halder G (2003) Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway. Nature Cell Biology 5:914-920.

Willecke M, Hamaratoglu F, Kango-Singh M, Udan R, Chen CL, Tao C, Zhang X, Halder G (2006) The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size. Current Biology 16:2090-2100.

Van Driessche N, Shaw C, Katoh M, Morio T, Sucgang R, Ibarra M, Kuwayama H, Saito T, Urushihara H, Maeda M, Takeuchi I, Ochiai H, Eaton W, Tollett J, Halter J, Kuspa A, Tanaka Y, Shaulsky G (2002) A transcriptional profile of multicellular development in Dictyostelium discoideum. Development 129:1543-1552.

Good JR, Cabral M, Sharma S, Yang J, Van Driessche N, Shaw CA, Shaulsky G, Kuspa A (2003) TagA, a putative serine protease/aBC transporter of Dictyostelium that is required for cell fate determination at the onset of development. Development 130:2953-2965.

Kibler K, Nguyen TL, Svetz J, Van Driessche N, Ibarra M, thompson C, Shaw C, Shaulsky G (2003) A novel developmental mechanism in Dictyostelium revealed in a screen for communication mutants. Developmental Biology 259:193-208.

Katoh M, Shaw C, Xu Q, Van Driessche N, Morio T, Kuwayama H, Obara S, Urushihara H, Tanaka Y, Shaulsky G (2004) An orderly retreat: Dedifferentiation is a regulated process. Proceedings of the National Academy of Sciences U.S.A. 101:7005-7010.

Van Driessche N, Demsar J, Booth EO, Hill P, Juvan P, Zupan P, Kuspa A, Shaulsky G (2005) Epistasis analysis with global transcriptional phenotypes. Nature Genetics 37:471-477.

Booth EO, Van Driessche N, Zhuchenko O, Kuspa A, Shaulsky G (2005) Microarray phenotyping in Dictyostelium reveals a regulon of chemotaxis genes. Bioinformatics 21:4371-4377.

Watase K, Venken KJT, Sun Y, Orr HT, Zoghbi HY (2003) Regional differences of somatic CAG repeat instability do not account for selective neuronal vulnerability in a knock-in mouse model of SCA1. Human Molecular Genetics 12:2789-2795.

Wallis D, Hamblen M, Zhou Y, Venken KJT, Schumacher A, Grimes HL, Zoghbi HY, Orkin SH, Bellen HJ. (2003) The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival. Development 130:221-232.

Kazanjian A, Wallis D, Au N, Nigam R, Venken KJT, Cagle PT, Dickey BF, Bellen HJ, Gilks CB, Grimes HL (2004) Growth factor independence-1 is expressed in primary human neuroendocrine lung carcinomas and mediates the differentiation of murine pulmonary neuroendocrine cells. Cancer Research 64:6874-6882.

Venken KJT, Bellen HJ (2005) Emerging technologies for gene manipulation in Drosophila melanogaster. Nature Reviews Genetics 6:167-178.

Verstreken P, Ly CV, Venken KJT, Koh TW, Zhou Y, Bellen HJ (2005) Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions. Neuron 47:365-378.

Tsuda H, Jafar-Nejad H, Patel AJ, Sun Y, Chen HK, Rose MF, Venken KJT, Botas J, Orr HT, Bellen HJ, Zoghbi HY (2005) The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins. Cell 122:633-644.

Shroyer NF, Wallis D, Venken KJT, Bellen HJ, Zoghbi HY (2005) Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation. Genes and Development 19:2412-2417.

Venken KJT, He Y, Hoskins RA, Bellen HJ (2006) P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster. Science 314:1747-1751.

Lloyd TE*, Verstreken P*, Ostrin EJ, Phillippi A, Lichtarge O, Bellen HJ. (2000) A genome-wide search for synaptic vesicle cycle proteins in Drosophila. Neuron 26: 45-50. (*The first two authors contributed equally to this work.)

Verstreken P, Bellen HJ (2001) The meaning of a mini. Science 293: 443-444.

Morales J, Hiesinger PR, Schroeder AJ, Kume K, Verstreken P, Jackson FR, Nelson DL, Hassan BA (2002) Drosophila fragile X protein, DFXR, regulates neuronal morphology and function in the brain. Neuron 34:961-972.

Verstreken P, Bellen HJ (2002) Meaningless minis? Mechanisms of neurotransmitter-receptor clustering. Trends in Neuroscience 25:383-385.

Verstreken P, Kjaerulff O, Lloyd TE, Atkinson R, Zhou Y, Meinertzhagen IA, Bellen HJ (2002) endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release. Cell 109:101-112.

Kjaerulff O, Verstreken P, Bellen HJ (2002) Synaptic vesicle retrieval: still time for a kiss. Nature Cell Biology 4:E245-E248.

Kango-Singh M, Nolo R, Tao C, Verstreken P, Hiesinger PR, Bellen HJ, Halder G (2002) Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila. Development 129:5719-5730.

Zhai RG, Hiesinger PR, Koh TW, Verstreken P, Schulze KL, Cao Y, Jafar-Nejad H, Norga KK, Pan H, Bayat V, Greenbaum MP, Bellen HJ (2003) Mapping Drosophila mutations with molecularly defined P element insertions. Proceedings of the National Academy of Sciences U.S.A. 100: 10860-10865.

Verstreken P*, Koh TW*, Schulze KL, Zhai RG, Hiesinger PR, Zhou Y, Mehta SQ, Cao Y, Roos J, Bellen HJ (2003) Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoating. Neuron 40:733-748. (*The first two authors contributed equally to this work.)

Fabian-Fine R, Verstreken P, Hiesinger PR, Horne JA, Kostyleva R, Zhou Y, Bellen HJ, Meinertzhagen IA (2003) Endophilin promotes a late step in endocytosis at glial invaginations in Drosophila photoreceptor terminals. Journal of Neuroscience 23:10732-10744.

Bermingham NA, Hassan BA, Wang VY, Fernandez M, Banfi S, Bellen HJ, Fritzsch B, Zoghbi HY (2001) Proprioceptor pathway development is dependent on Math1. Neuron 30: 411-422.

Wang VY, Zoghbi HY (2001) Genetic regulation of cerebellar development. Nature Reviews in Neuroscience 22: 484-491.

Wang VY, Hassan BA, Bellen HJ, Zoghbi HY (2002) Drosophila atonal fully rescues the phenotype of Math1 null mice: new functions evolve in new cellular contexts. Current Biology 12: 1611-1616.

Wang VY*, Rose MF*, Zoghbi HY (2005) Math1 expression redefines the rhombic lip and reveals novel lineages within the brainstem and cerebellum. Neuron 48:31-43. (*The first two authors contributed equally to this work.)

Yabut O, Renfro A, Niu S, Swann JW, Marin O, D'Arcangelo G (2005) Abnormal laminar position and dendrite development of interneurons in the reeler forebrain. Brain Research 1140:75-83.

Niu S, Yabut O, D'Arcangelo G (2008) The Reelin signaling pathway promotes dendritic spine development in hippocampal neurons. Journal of Neuroscience 28:10339-10348.

Zhang L, Mathers PH, Jamrich M (2000) Function of Rx, but not Pax6, is essential for the formation of retinal progenitor cells in mice. Genesis 28:135-142.

Zhang L, El-Hodiri HM, Ma HF, Zhang X, Servetnick M, Wensel TG, Jamrich M (2003) Targeted expression of the dominant-negative FGFR4a in the eye using Xrx1A regulatory sequences interferes with normal retinal development. Development 130:4177-4186.

Bailey TJ, El-Hodiri H, Zhang L, Shah R, Mathers PH, Jamrich M (2004) Regulation of vertebrate eye development by Rx genes. International Journal of Developmental Biology 48:761-770.