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Vascular remodeling and heart morphogenesis in early vertebrate embryos
My laboratory uses a multi-disciplinary approach to study the role of fluid-derived mechanical forces in
vascular remodeling and heart morphogenesis in early vertebrate embryos. We have recently developed methods for
time-lapse, confocal imaging of rapid blood flow and heart mechanics using vital fluorescent protein reporters. With
these methods we are studying the response to changes in mechanical stress in mouse and zebrafish models, taking
advantage of the wealth of mutant animals.
Selected Publications
Jones EA, Crotty D, Kulesa PM, Waters CW, Baron MH, Fraser SE, Dickinson ME (2002) Dynamic in
vivo imaging of postimplantation mammalian embryos using whole embryo culture. Genesis 34:228-235.
Dickinson ME, Simbuerger E, Zimmermann B, Waters CW, Fraser SE (2003) Multiphoton excitation spectra in biological
samples. Journal of Biomedical Optics 8:329-338.
Hadjantonakis AK, Dickinson ME, Fraser SE, Papaioannou VE (2003) Technicolour transgenics: imaging tools
for functional genomics in the mouse. Nature Reviews Genetics 4:613-625.
Nashmi R, Dickinson ME, McKinney S, Jareb M, Labarca C, Fraser SE, Lester HA (2003) Assembly of α4β2
nicotinic acetylcholine receptors assessed with functional fluorescently labeled subunits: effects of localization, trafficking,
and nicotine-induced upregulation in clonal mammalian cells and in cultured midbrain neurons. Journal of Neuroscience
23:11554-11567.
Jones EA, Baron MH, Fraser SE, Dickinson ME (2004) Measuring hemodynamic changes during mammalian development.
American Journal of Physiology - Heart and Circulatory Physiology 287:H1561-H1569.
Liebling M, Forouhar AS, Gharib M, Fraser SE, Dickinson ME (2005) Four-dimensional cardiac imaging in living
embryos via postacquisition synchronization of nongated slice sequences. Journal of Biomedical Optics 10:054001.
Fraser ST, Hadjantonakis AK, Sahr KE, Willey S, Kelly OG, Jones EA, Dickinson ME, Baron MH (2005) Using a histone
yellow fluorescent protein fusion for tagging and tracking endothelial cells in ES cells and mice. Genesis 42:162-171.
Wang J, Hamblet NS, Mark S, Dickinson ME, Brinkman BC, Segil N, Fraser SE, Chen P, Wallingford JB, Wynshaw-Boris A (2006)
Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation.
Development 133:1767-1778.
Forouhar AS, Liebling M, Hickerson A, Nasiraei-Moghaddam A, Tsai HJ, Hove JR, Fraser SE, Dickinson ME, Gharib M (2006)
The embryonic vertebrate heart tube is a dynamic suction pump. Science 312:751-753.
Lucitti JL, Dickinson ME (2006) Moving toward the light: using new technology to answer old questions.
Pediatric Research 60:1-5.
Liebling M, Forouhar AS, Wolleschensky R, Zimmermann B, Ankerhold R, Fraser SE, Gharib M, Dickinson ME (2006)
Rapid three-dimensional imaging and analysis of the beating embryonic heart reveals functional changes during development.
Developmental Dynamics 235:2940-2948.
Contact Information
- Mary Dickinson, Ph.D.
- Department of Molecular Physiology and Biophysics
- Baylor College of Medicine
- One Baylor Plaza BCM 335
- Houston, Texas 77030, U.S.A.
- Tel: (713) 798-2104
- Fax: (713) 798-3475
- E-mail: mdickins@bcm.tmc.edu
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