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Cellular and molecular mechanism of memory storage
The goal of my laboratory is to study the molecular and cellular mechanisms, as well as the neuronal circuitry, underlying long-term synaptic plasticity, learning and
memory. I believe that by studying the mechanisms underlying long-lasting synaptic plasticity and mnemonic processes we can generate corresponding insights into human cognitive disorders.
Our prior work established a critical role for translational control in long-lasting forms of synaptic plasticity and memory formation. Currently, our lab studies the molecular and cellular
mechanism underlying long-lasting synaptic plasticity and memory. To study these processes, in a multidisciplinary approach, we combine transgenic manipulation, shRNA and miRNA delivery using
lentiviral vectors, biochemical, imaging, behavioral and in vitro and in vivo neurophysiological methodologies.
In a complementary line of research, we intend to elucidate the mechanisms linking translational control with developmental disorders such as Autism and mental retardation and other neurological
disorders such as Alzheimer's disease.
Selected Publications
Costa-Mattioli M, Gobert D, Harding H, Herdy B, Azzi M, Bruno M, Bidinosti M, Ben Mamou C, Marcinkiewicz E, Yoshida M, et al. (2005) Translational control of hippocampal
synaptic plasticity and memory by the eIF2alpha kinase GCN2. Nature 436:1166-1173.
Costa-Mattioli M, Gobert D, Stern E, Gamache K, Cuello C, Sossin W, Kaufman R, Pelletier J, Rosenblum K, Krnjevic K, Lacaille J-C, Nader K, Sonenberg N (2007) eIF2a phosphorylation
regulates the switch from short to long-term synaptic plasticity and memory. Cell 129:195-206.
Colina R*, Costa-Mattioli M*, Dowling RJ, Jaramillo M, Tai LH, Breitbach CJ, Martineau Y, Larsson O, Rong L, Svitkin YV, Makrigiannis AP, Bell JC, Sonenberg N (2008) Translational control
of the innate immune response through IRF-7. Nature 452:323-328. (*equal contribution)
Costa-Mattioli M, Sonenberg N (2008) RAPping production of type I interferon in pDCs through mTOR. Nature Immunology 9:1097-1099.
Napoli I, Mercaldo V, Boyl PP, Eleuteri B, Zalfa F, De Rubeis S, Di Marino D, Mohr E, Massimi M, Falconi M, Witke W, Costa-Mattioli M, Sonenberg N, Achsel T, Bagni C (2008) The fragile
X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. Cell 134:1042-1054.
Costa-Mattioli M (2008) Eppendorf winner. Switching memories ON and OFF. Science 322:874-875.
Patel PH, Costa-Mattioli M, Schulze KL, Bellen HJ (2009) The Drosophila deoxyhypusine hydroxylase homologue nero and its target eIF5A are required for cell growth and the regulation of
autophagy. Journal of Cell Biology 185:1181-1194.
Petroulakis E, Parsyan A, Dowling RJ, LeBacquer O, Martineau Y, Bidinosti M, Larsson O, Alain T, Rong L, Mamane Y, Paquet M, Furic L, Topisirovic I, Shahbazian D, Livingstone M,
Costa-Mattioli M, Teodoro JG, Sonenberg N (2009) p53-dependent translational control of senescence and transformation via 4E-BPs. Cancer Cell 16:439-446.
Costa-Mattioli M, Sossin WS, Klann E, Sonenberg N (2009) Translational control of long-lasting synaptic plasticity and memory. Neuron 61:10-26.
Contact Information
- Mauro Costa-Mattioli, Ph.D.
- Department of Neuroscience
- Baylor College of Medicine
- One Baylor Plaza
- Houston, Texas 77030, U.S.A.
- Tel: (713) 798-8913
- Fax: (713) 798-3946
- E-mail: costamat@bcm.edu
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