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Robert S. McNeil
Senior Research
Coordinator Baylor College of Medicine email: rmcneil@bcm.edu Currently I work as Senior Research Coordinator facilitating several clinical research projects at Baylor College of Medicine (BCM) and Texas Children's Hospital (TCH) involving the development of new treatments for children affected by disorders of neurological development. As section webmaintainer, I create and manage sites for BCM Pediatric Neurology and Developmental Neuroscience, the Gordon and Mary Cain Pediatric Neurology Research Foundation Laboratories, TCH intranet sites for the Neurology Department and the Blue Bird Circle Clinic for Pediatric Neurology, a NIH Post-Doctoral Training Program website, and public TCH webpages for affiliated neurology clinics and faculty. Working in Dr. Gary Clark's lab in the Cain Foundation Laboratories, I participated in basic science research investigating neuronal migration disorders of human brain development. Research focused upon the Lis1, Reelin, Dab1, and DCX genetic pathways and the cytoskeletal basis of neuronal migration. Mutations of these genes cause impairments of neuronal migration, positioning and connectivity that often produce seizures, epilepsy and premature death in affected individuals. The images, videos and presentations shown below are representative of my work from the lab and are presented for educational purposes to stimulate interest in neuroscience research. For image use requests or questions please email: rmcneil@bcm.edu Neuronal Migration Movies
Time-lapse movies of in vitro neuronal migration.
Time-lapse movie of in vitro neuronal migration.
Time-lapse movie of neuronal migration in a hippocampal slice. Neuronal Growth Cone Movies
Time-lapse movie of neuronal growth cone pathfinding.
Time-lapse movie of two neuronal growth cones making contact.
Time-lapse movie of growth cone pathfinding and neuronal migration.
Time-lapse movie of growth cone pathfinding. Vesicular Trafficking Movie
Images of Neurons and Neuronal Proteins
Hippocampal neuron stained for spectrin (red) and tubulin (green).
Neuron transfected with doublecortin (DCX) DsRed and mannose phosphate receptor (MPR) GFP.
Neuron transfected with doublecortin (DCX) DsRed and mannose phosphate receptor (MPR) GFP.
Neurons transfected with doublecortin (DCX) DsRed and mannose phosphate receptor (MPR) GFP.
Neuron transfected with DCX DsRed and clathrin adaptor protein µ1A GFP.
Laser confocal images of neurons in hippocampal slice gene gun transfected with DCX DsRed and µ1A GFP.
Fluorescent and laser confocal images of a neuron in hippocampal slice gene gun transfected with DCX DsRed and µ1A GFP.
Laser confocal image of a neuron stained with LIS1/FITC and cytoplasmic dynein/TRITC. (Aumais et.al, J Neurosci. 2001 Dec 15;21(24):RC187, ©2001 Society for Neuroscience)
A neuronal growth cone stained for beta tubulin (green) and actin (red).
COS7 cell undergoing mitosis transfected with DCX DsRed and stained with gamma tubulin/FITC and DAPI.
COS7 cell undergoing mitosis transfected with DCX DsRed and µ1A GFP and stained with DAPI.
COS7 cell transfected with DCX DsRed and stained with dynein/FITC and DAPI.
COS7 cells transfected with DCX DsRed and MPR GFP.
COS7 cells transfected with DCX DsRed and stained with gamma tubulin/FITC and DAPI.
COS7 cells transfected with MPR GFP and stained with wheat germ agglutinin (WGA)/TRITC.
COS7 cell transfected with DCX DsRed and MPR GFP and stained with beta tubulin/Marina blue.
COS7 cells transfected with DCX DsRed and MPR GFP and stained with beta tubulin/Marina blue.
COS7 cells transfected with DCX DsRed and stained with golgin/FITC.
COS7 cell transfected with DCX DsRed and stained with beta tubulin/FITC.
COS7 cell transfected with LIS1GFP and DAB1 DsRed .
COS7 cell undergoing mitosis transfected with DCX DsRed and µ1a-GFP and and stained with DAPI. COS7 cells undergoing mitosis transfected with DCX DsRed and stained with gamma tubulin/FITC and DAPI. Neuroscience Presentations and Multimedia
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Baylor College of Medicine Last Modified: September 17, 2009
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