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Robert S. McNeil Section Webmaintainer Pediatric
Neurology and Developmental
Neuroscience, Department of Pediatrics email: rmcneil@bcm.eduCurrently I work as Senior Research Coordinator facilitating several clinical research projects at Baylor College of Medicine (BCM) and Texas Children's Hospital (TCH) involving the development of new treatments for children affected by disorders of neurological development. As
section webmaintainer, I create and manage
sites for BCM
Pediatric Neurology and Developmental Neuroscience, the Gordon and
Mary Cain
Pediatric Neurology Research Foundation Laboratories, TCH
intranet sites for the Neurology Department and the Blue
Bird Circle Clinic for Pediatric Neurology, a
NIH Post-Doctoral Training Program website, and public TCH
webpages
for affiliated
neurology clinics
and faculty. The images, videos and presentations shown below are representative of my work from the lab involving cell culture, transfection, staining, microscopic imaging, image processing and web preparation, and are presented for educational purposes to stimulate interest in neuroscience research. For image use requests or questions: email: rmcneil@bcm.eduNeuronal Migration Movies Time-lapse movies of in vitro neuronal migration.
Time-lapse movie of in vitro neuronal migration. Time-lapse movie of neuronal migration in a hippocampal slice. Neuronal Growth Cone Movies Time-lapse movie of neuronal growth cone pathfinding. Time-lapse movie of two neuronal growth cones making contact.
Time-lapse movie of growth cone pathfinding and neuronal migration. Time-lapse movie of growth cone pathfinding. Vesicular Trafficking Movie Images of Neurons and Neuronal Proteins
Hippocampal neuron stained for spectrin (red) and tubulin (green).
Neuron transfected with doublecortin (DCX) DsRed and mannose phosphate receptor (MPR) GFP. Neuron transfected with doublecortin (DCX) DsRed and mannose phosphate receptor (MPR) GFP.
Neurons transfected with doublecortin (DCX) DsRed and mannose phosphate receptor (MPR) GFP. Neuron transfected with DCX DsRed and clathrin adaptor protein µ1A GFP. Laser confocal images of neurons in hippocampal slice gene gun transfected with DCX DsRed and µ1A GFP. Fluorescent and laser confocal images of a neuron in hippocampal slice gene gun transfected with DCX DsRed and µ1A GFP. Laser confocal image of a neuron stained with LIS1/FITC and cytoplasmic dynein/TRITC. (Aumais et.al, J Neurosci. 2001 Dec 15;21(24):RC187, ©2001 Society for Neuroscience) A neuronal growth cone stained for beta tubulin (green) and actin (red). COS7 cell undergoing mitosis transfected with DCX DsRed and stained with gamma tubulin/FITC and DAPI. COS7 cell undergoing mitosis transfected with DCX DsRed and µ1A GFP and stained with DAPI. COS7 cell transfected with DCX DsRed and stained with dynein/FITC and DAPI. COS7 cells transfected with DCX DsRed and MPR GFP. COS7 cells transfected with DCX DsRed and stained with gamma tubulin/FITC and DAPI. COS7 cells transfected with MPR GFP and stained with wheat germ agglutinin (WGA)/TRITC.
COS7 cell transfected with DCX DsRed and MPR GFP and stained with beta tubulin/Marina blue.
COS7 cells transfected with DCX DsRed and MPR GFP and stained with beta tubulin/Marina blue.
COS7 cells transfected with DCX DsRed and stained with golgin/FITC.
COS7 cell transfected with DCX DsRed and stained with beta tubulin/FITC. COS7 cell transfected with LIS1GFP and DAB1 DsRed . COS7 cell undergoing mitosis transfected with DCX DsRed and µ1a-GFP and and stained with DAPI. COS7 cells undergoing mitosis transfected with DCX DsRed and stained with gamma tubulin/FITC and DAPI. Neuroscience Presentations and Multimedia>>>Society for Neuroscience 2005 Powerpoint Presentation<<< A Refined Method of Quantitative Cortical Analysis (must use Internet Explorer with MS Office XP or above) >>>Neural Odyssey
- a
movie
of neuroscience images and classical music<<< >>>Flash introduction for the Cain Foundation Labs<<< PublicationsAssadi AH, Zhang G, McNeil R, Clark GD, D'Arcangelo G. Pafah1b2 mutations suppress the development of hydrocephalus in compound Pafah1b1; Reln and Pafah1b1; Dab1 mutant mice. Neurosci Lett. 2008 Jul 4;439(1):100-5.Zhang G, Assadi AH, McNeil RS, Beffert U, Wynshaw-Boris A, Herz J, Clark GD, D'Arcangelo G. The Pafah1b complex interacts with the Reelin receptor VLDLR. PLoS ONE. 2007 Feb 28;2(2):e252. Assadi AH, Zhang G, Beffert U, McNeil RS, Renfro AL, Niu S, Quattrocchi CC, Antalffy BA, Sheldon M, Armstrong DD, Wynshaw-Boris A, Herz J, D'Arcangelo G, Clark GD. Interaction of reelin signaling and Lis1 in brain development. Nat Genet. 2003 Nov;35(3):270-6. Epub 2003 Oct 26. Aumais JP, Tunstead JR, McNeil RS, Schaar BT, McConnell SK, Lin SH, Clark GD, Yu-Lee LY. NudC associates with Lis1 and the dynein motor at the leading pole of neurons. J Neurosci. 2001 Dec 15;21(24):RC187. Clark GD, Zorumski CF, McNeil RS, Happel LT, Ovella T, McGuire S, Bix GJ, Swann JW. Neuronal platelet-activating factor receptor signal transduction involves a pertussis toxin-sensitive G-protein. Neurochem Res. 2000 May;25(5):603-11. Hamra M, McNeil RS, Runciman M, Kunze DL. Opioid modulation of calcium current in cultured sensory neurons: mu-modulation of baroreceptor input. Am J Physiol. 1999 Aug;277(2 Pt 2):H705-13. McNeil RS, Swann JW, Brinkley BR, Clark GD. Neuronal cytoskeletal alterations evoked by a platelet-activating factor (PAF) analogue. Cell Motil Cytoskeleton. 1999;43(2):99-113. Hamra M, McNeil RS. Accentuated antagonism in canine subendocardium is not altered by chronic exercise. Med Sci Sports Exerc. 1997 Aug;29(8):1013-20. Clark GD, McNeil RS, Bix GJ, Swann JW. Platelet-activating factor produces neuronal growth cone collapse. Neuroreport. 1995 Dec 15;6(18):2569-75. Clark GD, McNeil RS, Bix GJ, Swann JW. Lipids as axon guidance molecules? Neuroreport. 1995 Dec 15;6(18):2446. Hamra M, McNeil RS. Cardiac adrenergic responses and electrophysiology during ischemia: effect of exercise. Med Sci Sports Exerc. 1995 Jul;27(7):993-1002. Contact Information: Robert S.
McNeil
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