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Scientific Director
- The Gordon and Mary Cain Pediatric Neurology Research
Foundation Laboratories
Professor -
Department of Pediatrics and Division of Neuroscience, Baylor
College of Medicine
B.S., University of Maryland, 1968
M.S., University of Maryland, 1973
Ph.D., University of Maryland, 1974
Research Interests:
Epileptogenesis
In Developing Neural Networks
The focus of
our laboratory is to understand the biological origins of
intractable seizure disorders in the developing brain. The
childhood epilepsies are among the most severe neurological
syndromes of early life. A multidisciplinary approach is taken
to develop animal models that are relevant to particular forms
of epilepsy.
Current studies attempt to understand
maturational differences in focal seizure of the
temporal lobe, particularly the CA3 subfield of the
hippocampus. In vivo and in vitro electrophysiological studies
are coupled with detailed microanatomical investigations of
developing hippocampal neural networks.
In addition long term
alterations in the physiological properties of individual
cells and patterns of connectivity produced by early life
seizures are examined. Identification of the molecular steps
involved in the production of chronic epileptic conditions are
our ultimate goal since these will likely lead to therapies
that will prevent the formation of epileptogenic neural
network.
Selected
Publications:
Swann JW, Le JT, Lee CL.
Recurrent seizures and the molecular maturation of hippocampal
and neocortical glutamatergic synapses. Dev Neurosci. 2007;29(1-2):168-78.
Yabut O, Renfro A, Niu S, Swann JW, Marin O, D'Arcangelo G. Abnormal laminar position and dendrite development of interneurons in the reeler forebrain. Brain Res. 2007 Apr 6;1140:75-83. Epub 2006 Sep 22.
Ljungberg MC, Bhattacharjee MB, Lu Y, Armstrong DL, Yoshor D, Swann JW, Sheldon M, D'Arcangelo G. Activation of mammalian target of rapamycin in cytomegalic neurons of human cortical dysplasia. Ann Neurol. 2006 Oct;60(4):420-9.
Galvan,
C.D., Wenzel, J.H., Dineley, K., Lam, T., Schwartzkroin, P.A.,
Sweatt, J.D. and Swann, J.W. Postsynaptic
Contributions to Hippocampal Network Hyperexcitability Induced
by Chronic Activity Blockade in Vivo. European Journal of
Neuroscience,18:1861-1872, 2003.
Oliva, A.A.
Jr., Lam, T. and and Swann, J.W. Distally-Directed
Dendrotoxicity Induced by Kainic Acid in Hippocampal
Interneurons of GFP-Expressing (GIN) Transgenic Mice. J.
Neuroscience, 22:8052-8062, 2002.
Lee,C.L.,
Hannay, J., Hrachovy, R., Rashid, S., Antalffy, B. and
Swann, J.W. Recurrent seizures in infant rats produce
spatial learning deficits without a substantial loss of
hippocampal pyramidal cells. Neuroscience, 107:71-84, 2001.
Jiang, M.,
Oliva, A.A. Jr., Lam, T. and and Swann, J.W. GABAergic
Neurons That Pioneer Hippocampal Area CA1 of the Mouse:
Morphological Features and Multiple Fates. Journal of
Comparative Neurology, 439:176-192, 2001.
Contact Information:
John Swann
Ph.D.
The Cain Foundation Laboratories
The Feigin Center, Suite 955 MC 3-6365
1102 Bates Street
Houston, Texas 77030
Tel: 832-824-3969
Email: jswann@bcm.tmc.edu
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(c)1998-2006 Baylor College of
Medicine
Cain Foundation Pediatric Neurology Research
Foundation Laboratories
Feigin Center, Suite 955, Texas Children's Hospital
1102 Bates Avenue, MC 3-6365
Houston, TX 77030
Phone: 832-824-3968 | Fax:
832-825-4217
E-mail:
Cain_Found@bcm.tmc.edu
Last Modified: May 3,
2007
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