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Co-Director, Jan and Dan
Duncan
Neurological
Research Institute
Scientific
Director
- The Gordon and Mary Cain Pediatric
Neurology Research Foundation Laboratories
Professor
- Department of Pediatrics and Division of Neuroscience, Baylor College
of Medicine
B.S.,
University of Maryland, 1968
M.S., University of Maryland, 1973
Ph.D., University of Maryland, 1974
Research
Interests:
Epileptogenesis
In Developing Neural Networks
The
focus of our laboratory is to understand the biological origins of
intractable seizure disorders in the developing brain. The childhood
epilepsies are among the most severe neurological syndromes of early
life. A multidisciplinary approach is taken to develop animal models
that are relevant to particular forms of epilepsy.
Current
studies attempt to understand maturational differences in focal
seizure of the temporal lobe, particularly the CA3 subfield of
the hippocampus. In vivo and in vitro electrophysiological studies are
coupled with detailed microanatomical investigations of developing
hippocampal neural networks.
In
addition long term alterations in the physiological properties of
individual cells and patterns of connectivity produced by early life
seizures are examined. Identification of the molecular steps involved
in the production of chronic epileptic conditions are our ultimate goal
since these will likely lead to therapies that will prevent the
formation of epileptogenic neural network.
Selected
Publications:
Jacobs
MP,
Leblanc GG, Brooks-Kayal A, Jensen FE, Lowenstein DH, Noebels JL,
Spencer DD, Swann,
JW.
Curing epilepsy: progress and future
directions. Epilepsy Behav. 2009 Mar;14(3):438-45.
Swann,
JW.
The spine loss paradox: clues to mechanisms and
meaning. Epilepsy Curr. 2008 Nov-Dec;8(6):168-9.
Nishimura M, Owens J, Swann,
JW.
Effects of chronic network
hyperexcitability on the growth of hippocampal dendrites.
Neurobiol Dis. 2008 Feb;29(2):267-77. Epub 2007 Sep 12.
Lee CL, Frost JD Jr, Swann,
JW,
Hrachovy RA. A new animal
model of infantile spasms with unprovoked persistent
seizures. Epilepsia. 2008 Feb;49(2):298-307. Epub 2007 Oct 16.
Swann,
JW,
Le JT, Lam TT, Owens J, Mayer AT. The impact of
chronic network hyperexcitability on developing glutamatergic
synapses. Eur J Neurosci. 2007 Aug;26(4):975-91.
Swann,
JW,
Le
JT,
Lee CL.
Recurrent seizures and the molecular maturation of
hippocampal
and neocortical glutamatergic synapses. Dev Neurosci.
2007;29(1-2):168-78.
Yabut
O,
Renfro A, Niu S, Swann,
JW,
Marin O, D'Arcangelo G. Abnormal laminar
position and dendrite development of interneurons in the reeler
forebrain. Brain Res.
2007 Apr 6;1140:75-83. Epub 2006 Sep 22.
Ljungberg MC,
Bhattacharjee
MB,
Lu Y, Armstrong DL, Yoshor D, Swann,
JW, Sheldon M,
D'Arcangelo G. Activation
of mammalian target of rapamycin in cytomegalic neurons of human
cortical dysplasia. Ann Neurol. 2006 Oct;60(4):420-9.
Galvan,
C.D., Wenzel, J.H.,
Dineley, K., Lam, T., Schwartzkroin, P.A., Sweatt, J.D. and Swann,
J.W.
Postsynaptic
Contributions to Hippocampal
Network Hyperexcitability Induced by Chronic Activity Blockade in Vivo.
European Journal of Neuroscience,18:1861-1872, 2003.
Oliva,
A.A. Jr., Lam, T. and and Swann,
J.W.
Distally-Directed
Dendrotoxicity Induced by Kainic Acid in Hippocampal Interneurons of
GFP-Expressing (GIN) Transgenic Mice. J. Neuroscience,
22:8052-8062, 2002.
Lee,C.L.,
Hannay, J., Hrachovy, R.,
Rashid, S., Antalffy, B. and Swann,
J.W.
Recurrent seizures in infant rats produce spatial learning deficits
without a substantial loss of hippocampal pyramidal cells.
Neuroscience, 107:71-84, 2001.
Jiang,
M.,
Oliva, A.A. Jr., Lam, T. and and Swann,
J.W.
GABAergic Neurons That Pioneer Hippocampal Area CA1 of the Mouse:
Morphological Features and Multiple Fates. Journal of
Comparative Neurology, 439:176-192, 2001.
Contact
Information:
John
Swann
Ph.D.
The Cain Foundation Laboratories
The Feigin Center, Suite 955 MC 3-6365
1102 Bates Street
Houston, Texas 77030
Tel: 832-824-3969
Email: jswann@bcm.tmc.edu
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(c)1998-2006
Baylor College of Medicine
Gordon and
Mary
Cain Pediatric Neurology Research Foundation Laboratories
Feigin Center, Suite 955, Texas Children's Hospital
1102 Bates Avenue, MC 3-6365
Houston, TX 77030
Phone:
832-824-3968 | Fax:
832-825-4217
E-mail: Cain_Found@bcm.tmc.edu
Last Modified:
September 17, 2009
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