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Chief,
Neurology and
Developmental Neuroscience, Texas Children’s Hospital
Professor, Departments of Pediatrics and
Neurology,
Baylor College of Medicine
B.S.,
Louisiana State University, 1978
M.D., Louisiana State University, 1982
Post-Doc, Washington University, 1990
Clinical
Interests:
Developmental
neurological disorders, neuronal migration disorders.
Research Interests:
Our
research
is aimed at elucidating the cellular and molecular mechanisms involved
in brain development, with particular interest focused upon disorders
of neuronal migration, such as those seen in cases of lissencephaly. We
are currently investigating the lissencephaly associated genes Lis1
(Pafah1b1), Reelin (Reln),
and Doublecortin (DCX) and the
genetic and biochemical roles they play in neuronal migration and brain
development.
Selected
Publications:
Zhang
G, Assadi AH, Roceri M, Clark GD,
D'Arcangelo G. Differential interaction of the Pafah1b alpha
subunits with the Reelin transducer Dab1. Brain Res. 2009 Apr
24;1267:1-8.
Dobyns WB, Mirzaa G, Christian SL, Petras K, Roseberry J, Clark GD,
Curry CJ, McDonald-McGinn D, Medne L, Zackai E, Parsons J, Zand DJ,
Hisama FM, Walsh CA, Leventer RJ, Martin CL, Gajecka M, Shaffer
LG. Consistent chromosome abnormalities identify novel
polymicrogyria loci in 1p36.3, 2p16.1-p23.1, 4q21.21-q22.1, 6q26-q27,
and 21q2. Am J Med Genet A. 2008 Jul 1;146A(13):1637-54.
Assadi AH,
Zhang
G, McNeil R, Clark GD,
D'Arcangelo G. Pafah1b2 mutations suppress the
development of hydrocephalus in compound Pafah1b1; Reln and Pafah1b1;
Dab1 mutant mice. Neurosci Lett. 2008 Jul 4;439(1):100-5.
Berg
JS,
Brunetti-Pierri N, Peters SU, Kang SH, Fong CT, Salamone J, Freedenberg
D, Hannig VL, Prock LA, Miller DT, Raffalli P, Harris DJ, Erickson RP,
Cunniff C, Clark
GD, Blazo MA, Peiffer DA,
Gunderson KL, Sahoo T, Patel
A, Lupski JR, Beaudet AL, Cheung SW. Speech delay and autism
spectrum
behaviors are frequently associated with duplication of the 7q11.23
Williams-Beuren syndrome region. Genet Med. 2007
Jul;9(7):427-41.
Zhang
G, Assadi AH, McNeil RS, Beffert
U, Wynshaw-Boris A, Herz J, Clark GD,
D'Arcangelo
G.
The Pafah1b complex
interacts with the Reelin receptor VLDLR. PLoS ONE. 2007 Feb
28;2(2):e252.
Assadi
AH,
Zhang G, Beffert U, McNeil RS, Renfro AL, Niu S,Quattrochi CC, Antalffy
BA, Sheldon M, Wynshaw-Boris A, Armstrong DD, Herz J, D'Arcangelo G, Clark
GD. Interaction of
reelin signaling and Lis1 in
brain development. Nature
Genetics.
2003 Nov;35(3):270-6.
Yan W,
Assadi
AH, Wynshaw-Boris A, Eichele G, Matzuk MM, Clark GD.
Previously uncharacterized roles of platelet-activating factor
acetylhydrolase 1b complex in mouse spermatogenesis. Proc
Natl Acad Sci USA. 2003
June
10;100(12):7189-94.
Poolos
NP, Das
S, Clark GD,
Lardizabal D, Noebels JL, Wyllie E,
Dobyns WB. Males with epilepsy, complete subcortical band
heterotopia, and somatic mosaicism for DCX. Neurology.
2002 May 28;58(10):1559-62.
Aumais
JP,
Tunstead JR, McNeil RS, Schaar BT, McConnell SK, Lin SH, Clark
GD,
Yu-Lee
LY. NudC associates with Lis1 and the dynein motor at the
leading pole of neurons. J
Neurosci. 2001
Dec 15;21(24):RC187.
McNeil
RS,
Swann JW, Brinkley BR, Clark GD.:
Neuronal cytoskeletal alterations evoked by a platelet-activating
factor (PAF) analogue. Cell
Motil Cytoskeleton.
43(2): 99-113,1999.
Contact
Information:
Gary D.
Clark,
M.D.
The Cain Foundation Laboratories
The Feigin Center, Suite 955 MC 3-6365
1102 Bates Street
Houston, Texas 77030
Tel: 832-824-3963
Email: gclark@bcm.tmc.edu
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(c)1998-2006
Baylor College of Medicine
Gordon and
Mary
Cain Pediatric Neurology Research Foundation Laboratories
Feigin Center, Suite 955, Texas Children's Hospital
1102 Bates Avenue, MC 3-6365
Houston, TX 77030
Phone:
832-824-3968 | Fax:
832-825-4217
E-mail: Cain_Found@bcm.tmc.edu
Last Modified:
September 17, 2009
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