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Gary D. Clark, M.D.
Chief, Neurology and Developmental Neuroscience, Texas Children’s Hospital, Associate Professor Departments of Pediatrics and Neurology; Director, Child Neurology Residency Program, Baylor College of Medicine
B.S.,
Louisiana State University, 1978 Clinical Interests: Developmental
neurological disorders, neuronal migration disorders. Our research is aimed at elucidating the cellular and molecular mechanisms involved in brain development, with particular interest focused upon disorders of neuronal migration, such as those seen in cases of lissencephaly. We are currently investigating the lissencephaly associated genes Lis1 (Pafah1b1), Reelin (Reln), and Doublecortin (DCX) and the genetic and biochemical roles they play in neuronal migration and brain development. Selected Publications:Assadi AH, Zhang G, Beffert U, McNeil RS, Renfro AL, Niu S,Quattrochi CC, Antalffy BA, Sheldon M, Wynshaw-Boris A, Armstrong DD, Herz J, D'Arcangelo G, Clark GD. Interaction of reelin signaling and Lis1 in brain development. Nature Genetics. 2003 Nov;35(3):270-6. (PDF) Yan W, Assadi AH, Wynshaw-Boris A, Eichele G, Matzuk MM, Clark GD. Previously uncharacterized roles of platelet-activating factor acetylhydrolase 1b complex in mouse spermatogenesis. Proc Natl Acad Sci USA. 2003 June 10;100(12):7189-94. (PDF) Poolos NP, Das S, Clark GD, Lardizabal D, Noebels JL, Wyllie E, Dobyns WB. Males with epilepsy, complete subcortical band heterotopia, and somatic mosaicism for DCX. Neurology. 2002 May 28;58(10):1559-62. Aumais JP, Tunstead JR, McNeil RS, Schaar BT, McConnell SK, Lin SH, Clark GD, Yu-Lee LY. NudC associates with Lis1 and the dynein motor at the leading pole of neurons. J Neurosci. 2001 Dec 15;21(24):RC187. (PDF) McNeil RS, Swann JW, Brinkley BR, Clark GD.: Neuronal cytoskeletal alterations evoked by a platelet-activating factor (PAF) analogue. Cell Motil Cytoskeleton. 43(2): 99-113,1999. (PDF) Contact Information: Gary D. Clark,
M.D.
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