Chong L. Lee, Ph.D.

Assistant Professor, Department of Pediatrics, Division of Neuroscience, Baylor College of Medicine.

B.A., California State University, Fresno, CA, 1975
Ph.D., University of California at Barkley, CA, 1981

Research Interests:

Since 1992 my research has focused on developing a model of epileptogenesis during early life and the consequences of repeated seizures during the neonatal period on the development of the hippocampus. Results suggest that repeated early life seizures initiate rapid alterations in expression of neurotransmitter receptors that appears to persist well into adulthood.  Further studies suggest persistent alterations in hippocampal neuronal morphology and deficits in cognitive functions. Future studies are focused on further elucidation of seizures induced regulation of receptor expression. 

Selected Publications:

Swann JW, Smith KL, Lee CL. Neuronal activity and the establishment of normal and epileptic circuits during brain development. Int Rev Neurobiol. 2001;45:89-118.

Lee CL, Hannay J, Hrachovy R, Rashid S, Antalffy B, Swann JW. Spatial learning deficits without hippocampal neuronal loss in a model of early-onset epilepsy. Neuroscience. 2001;107(1):71-84.

Swann JW, Lee CL, Smith KL, Hrachovy RA. Developmental neuroplasticity and epilepsy. Epilepsia. 2000 Aug;41(8):1078-9.

Swann JW, Al-Noori S, Jiang M, Lee CL. Spine loss and other dendritic abnormalities in epilepsy. Hippocampus. 2000;10(5):617-25.

Swann JW, Pierson MG, Smith KL, Lee CL. Developmental neuroplasticity: roles in early life seizures and chronic epilepsy. Adv Neurol. 1999;79:203-16.

Jiang M, Lee CL, Smith KL, Swann JW. Spine loss and other persistent alterations of hippocampal pyramidal cell dendrites in a model of early-onset epilepsy. Journal of  Neuroscience. 1998 Oct 15;18(20):8356-68.

Smith KL, Lee CL, Swann JW. Local circuit abnormalities in chronically epileptic rats after intrahippocampal tetanus toxin injection in infancy. J Neurophysiol. 1998 Jan;79(1):106-16.

Lee CL, Hrachovy RA, Smith KL, Frost JD Jr, Swann JW. Tetanus toxin-induced seizures in infant rats and their effects on hippocampal excitability in adulthood. Brain Res. 1995 Apr 17;677(1):97-109.

Contact Information:

Chong L. Lee, Ph.D.
The Cain Foundation Laboratories
The Feigin Center, Suite 955 MC 3-6365
1102 Bates Street
Houston, Texas 77030
Tel: 832-824-3984
Email: clee@bcm.tmc.edu

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(c)1998-2006 Baylor College of Medicine
Gordon and Mary Cain Pediatric Neurology Research Foundation Laboratories
   Feigin Center, Suite 955, Texas Children's Hospital
1102 Bates Avenue, MC 3-6365
Houston, TX 77030
Phone: 832-824-3968 | Fax: 832-825-4217
E-mail: Cain_Found@bcm.tmc.edu

Last Modified: April 26, 2006