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Anesthesiology

Houston, Texas

Baylor College of Medicine's Department of Anesthesiology is located in the heart of the Texas Medical Center
Anesthesiology
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Cerebrovascular Research Laboratory

Elke Sokoya, Ph.D.
Assistant Professor

Research Interests

estrogen, gap junctions, cell-cell communication

Current Posters

Experimental Biology, 2007

Address

One Baylor Plaza, Suite 433D
Houston, TX, 77030
Tel: 713-798-7724
Fax: 713-798-7644
Email: egolding@bcm.edu

Education

James Cook University, Australia:
Ph.D., 1997

Description of Research

My laboratory focuses on understanding the mechanisms associated with sex differences in the cerebral vasculature. Our long term goal is to determine the mechanisms adopted by females in controlling cerebral vascular function. In contrast to peripheral vessels, we have shown that female rats have a reduced dilation to endothelium-dependent hyperpolarizing factor (EDHF) in the middle cerebral artery compared to males and that this effect is due to estrogen. Our efforts are currently focused on understanding the role of sex hormone status on vascular endothelial function

Another focus of our lab is in understanding how cells communicate with one another. Metabolic and electrical activity can be communicated to neighboring cells via gap junctions that can be selectively and exquisitely gated. We are interested in defining the role of gap junctions in mediating vascular function, and particularly that related to EDHF responses. Our studies have employed the use of sharp microelectrode and patch clamp techniques, perfused and pressurized isolated arteries, fura 2 fluorescence, electron microscopy and immunogold labeling, immunoblotting, immunocytochemistry and deconvolution microscopy, and RT-PCR.

Selected Publications

  • Sokoya EM, You, J, Chen, J: DCEBIO-mediated dilations are attenuated in the female rat middle cerebral artery Journal of Vascular Research 44:169-174, 2007Medline Link
  • Sokoya EM, You, J: Impaired cAMP signaling does not account for the attenuated EDHF-mediated dilations in female rat middle cerebral artery Brain Research 1139:29-33, 2007Medline Link
  • Sokoya EM, Burns RA, Setiawan CT, Coleman HA, Parkington, HC, Tare M: EDHF-mediated relaxations and the essential role of myoendothelial communication in the rat middle cerebral artery American Journal of Physiology 291: H385-H393, 2006. Medline Link
  • Bryan Jr RM, You J, Golding EM, Marrelli, SP: Endothelium-derived hyperpolarizing factor. A cousin to nitric oxide and prostacyclin. Anesthesiology 102(6): 1261-1277, 2005. Medline Link
  • Bryan Jr RM, Golding EM, You J: Arachidonic acid metabolites, hydrogen peroxide, and EDHF in cerebral arteries. American Journal of Physiology 289: H1077-1083, 2005. Medline Link
  • Golding EM, Robertson CS, Fitch JCK, Goodman JC, Bryan Jr RM: Segmental vascular resistance after mild controlled cortical impact injury in the rat. Journal of Cerebral Blood Flow and Metabolism 23(2): 210-218, 2003. Medline Link
  • Golding EM, Ferens DM, Marrelli SP: Altered calcium dynamics do not account for the attenuation of EDHF-mediated dilations in the female middle cerebral artery. Stroke 33: 2792-2977, 2002. Medline Link
  • Golding EM and Golding RM: Controlling and monitoring polymyositis under steroid therapy. Medical Hypotheses 59: 674-681, 2002. Medline Link
  • Golding EM, Bryan RM, Golding RM: The effect of surgery and severe injury on blood vessels. Physiological Measurement 23: 615-628, 2002. Medline Link
  • Golding EM: Sequelae following traumatic brain injury: the cerebrovascular perspective. Brain Research Reviews 38: 377-388, 2002. Medline Link
  • Golding EM, Marelli SP, You J, Bryan Jr RM: Endothelium-derived hyperpolarizing factor in the brain: a new regulator of cerebral blood flow? Stroke 33: 661-663, 2002. Medline Link
  • Golding EM and Golding RM: Mathematical modelling of responses of cerebral blood vessels to changing intraluminal pressure. Physiological Measurement 22: 727-743, 2001. Medline Link
  • Golding EM, You J, Robertson CS, Bryan Jr RM: Potentiated endothelium-derived hyperpolarizing factor-mediated dilations in cerebral arteries following mild head injury. Journal of Neurotrauma 18(7): 691-697, 2001. Medline Link
  • Golding EM and Golding RM: An insight into cortisol and polymyositis control with steroid therapy. Medical Hypotheses 57: 76-86, 2001. Medline Link
  • Golding EM, Steenberg ML, Johnson TD, Bryan Jr RM: Nitric oxide in the potassium-induced response of the rat middle cerebral artery: a possible permissive role. Brain Research 889: 98-104, 2001. Medline Link
  • Golding EM and Kepler TE: The role of estrogen in modulating EDHF-mediated dilations in the isolated rat middle cerebral artery. American Journal of Physiology 280: H2417-2423, 2001. Medline Link
  • Golding EM, Steenberg ML, Johnson TD, Bryan Jr RM: The effects of potassium on the rat middle cerebral artery. Brain Research 880: 159-166, 2000. Medline Link
  • Golding EM, Robertson CS, Bryan Jr RM: L-arginine partially restores the diminished CO2 reactivity following mild controlled cortical impact injury in the adult rat. Journal of Cerebral Blood Flow and Metabolism 20: 820-828, 2000. Medline Link
  • Golding EM, Steenberg ML, Contant Jr CF, Krishnappa I, Robertson CS, Bryan Jr RM: Cerebrovascular reactivity to CO2 and hypotension after mild cortical impact injury. American Journal of Physiology 277: H1457-H1466, 1999. Medline Link
  • Golding EM, Robertson CS, Bryan Jr RM: The consequences of traumatic brain injury on cerebral blood flow and autoregulation: a review. Clinical and Experimental Hypertension 21(4): 299-332, 1999. Medline Link
  • Golding EM and Golding RM: A mathematical assessment of the precision of parameters in measuring resonance spectra. Journal of Magnetic Resonance 135: 380-405, 1998. Medline Link
  • Golding EM, Contant Jr CF, Robertson CS, Bryan Jr RM: Temporal effect of severe controlled cortical impact injury in the rat on the myogenic response of the middle cerebral artery. Journal of Neurotrauma 15(11): 973-984, 1998. Medline Link
  • Golding EM, Steenberg ML, Cherian L, Marrelli SP, Robertson CS, Bryan Jr RM: Endothelial-mediated dilations following severe controlled cortical impact injury in the rat middle cerebral artery. Journal of Neurotrauma 15(8): 633-642, 1998. Medline Link
  • Golding EM, Robertson CS, Bryan Jr RM: Comparison of the myogenic response in rat cerebral arteries of different calibers. Brain Research 785(2): 293-298, 1998. Medline Link
  • Vink R, Golding EM, Williams JP, McIntosh TK: Blood glucose concentration does not affect outcome in brain trauma: a 31P MRS study. Journal of Cerebral Blood Flow and Metabolism 17(1): 50-53, 1997. Medline Link
  • Teague Jr WE, Golding EM, Dobson GP: Adjustment of K' for the creatine kinase, adenylate kinase and ATP hydrolysis equilibria to varying temperature and ionic strength. Journal of Experimental Biology 199(2): 509-512, 1996. Medline Link
  • Golding EM, Dobson GP, Golding RM: A critical assessment of noise-induced errors in 31P MRS: application to the measurement of free intracellular magnesium in vivo. Magnetic Resonance in Medicine 35: 174-185, 1996. Medline Link
  • Golding EM, Teague Jr WE, Dobson GP: Adjustment of K' to varying pH and pMg for the creatine kinase, adenylate kinase and ATP hydrolysis equilibria permitting quantitative bioenergetic assessment. Journal of Experimental Biology 198(8): 1775-1782, 1995. Medline Link
  • Golding EM and Golding RM: Interpretation of 31P MRS spectra in determining free magnesium and potassium ion concentrations. Magnetic Resonance in Medicine 33: 467-474, 1995. Medline Link
  • Golding EM and Vink R: Efficacy of competitive versus noncompetitive blockade of the NMDA channel following traumatic brain injury is associated with restoration of magnesium homeostasis. Molecular and Chemical Neuropathology 24(2-3): 137-150, 1995. Medline Link
  • Golding EM and Vink R: Inhibition of phospholipase C with neomycin improves metabolic and neurologic outcome following traumatic brain injury. Brain Research 668(1-2): 46-53, 1994. Medline Link
  • Vink R and Golding EM: Intracellular free magnesium: a critical factor in determining outcome after neurotrauma. Recent Advances in Neurotraumatology 425-430: 1994.
  • Golding EM, McIntosh TK, Williams JP, Vink R: Blood glucose concentration does not affect outcome following moderate brain trauma in rats. Recent Advances in Neurotraumatology 537-541, 1994.
  • Vink R, Golding EM, Headrick JP: Bioenergetic analysis of oxidative metabolism following traumatic brain injury in rats. Journal of Neurotrauma 11(3): 265-274, 1994. Medline Link