Cerebrovascular Research Laboratory Faculty
Jon Andresen, Ph.D.
Postdoctoral Fellow
Research Interests
cerebral vessels, carbon monoxide, K2P Channels
Current Posters
Address
One Baylor Plaza, Suite 433D
Houston, TX, 77030
Tel: 713-798-7720
Fax: 713-798-7644
Email: andresen@bcm.edu
Education
University of Iowa:
Ph.D. in neuroscience.
Description of Research
I am interested in the physiology of cerebral blood vessels. Currently, my research focuses on the heme oxygenase/carbon monoxide system as well as tandem pore domain potassium channels in rat and mouse cerebral vessels. The heme oxygenase system produces carbon monoxide endogenously and carbon monoxide is a vasodilator in some vessel beds. I am studying heme oxygenase systems influence on the function of cerebral vessels using pharmacological inhibitors as well as with heme oxygenase-2 knockout mice. Tandem pore domain potassium channels are a relatively recently discovered class of potassium channels that have interesting properties. For instance, some of these channels are inhibited by inhalation anesthetics and others are activated by arachidonic acid. I am studying tandem pore domain potassium channels by examining the electrophysiological properties of isolated cerebrovascular smooth muscle cells using the patch clamp technique.
Selected Publications
- Andresen JJ, Faraci FM, and Heistad DD: Vasomotor responses in MnSOD-deficient mice.Am J Physiol Heart Circ Physiol. 287:H1141-1148, 2004.
- Watanabe Y, Chu Y, Andresen JJ, Nakane H, Faraci FM, and Heistad DD: Gene transfer of extracellular superoxide dismutase reduces cerebral vasospasm after subarachnoid hemorrhageStroke 34:434-440, 2003.